{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:10:25Z","timestamp":1791216625898,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T00:00:00Z","timestamp":1401062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dentaid SL, Spain (provided products)"},{"DOI":"10.13039\/501100005075","name":"University Medical Center Groningen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005075","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this randomized, double\u2010blind, controlled trial was to evaluate the clinical, radiographic, and microbiological effects of implant surface decontamination with a 2% chlorhexidine (<jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>) solution in comparison with a 0.12% chlorhexidine\u00a0+\u00a00.05% cetylpyridinium chloride (<jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>) solution during resective surgical peri\u2010implantitis treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Forty\u2010four patients (108 implants) with peri\u2010implantitis were treated with resective surgical treatment consisting of bone re\u2010contouring, surface debridement and chemical decontamination, and apically repositioned flap. Patients were randomly allocated to decontamination with a 2% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> solution (test group) or 0.12% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\u00a0+\u00a00.05% <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content> (control group). Clinical and radiographic parameters were recorded before treatment (baseline), and at 3, 6, and 12\u00a0months after treatment. Microbiological parameters were recorded during surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multilevel analysis showed no significant differences in bleeding, suppuration, probing pocket depth, and radiographic bone loss between control and test group over three follow\u2010up measurements (3, 6, and 12\u00a0months) from baseline. Both decontamination procedures resulted in significant reductions in anaerobic bacterial counts on the implant surface, but no significant difference was noted between control and test group (mean log 3.37\u00a0\u00b1\u00a02.34 vs. 3.65\u00a0\u00b1\u00a02.87, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.99).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of a 2% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> solution for implant surface decontamination during resective peri\u2010implantitis therapy does not lead to improved clinical, radiographic, or microbiological results compared with a 0.12% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\u00a0+\u00a00.05% <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content> solution. Overall, the additional use of <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> reduces anaerobic bacterial load on the implant surface better than mechanical debridement alone, but does not seem to enhance clinical treatment outcomes (ClinicalTrials.gov number <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01852253).<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12419","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T07:36:36Z","timestamp":1401089796000},"page":"1015-1023","source":"Crossref","is-referenced-by-count":81,"title":["Implant decontamination with 2% chlorhexidine during surgical peri\u2010implantitis treatment: a randomized, double\u2010blind, controlled trial"],"prefix":"10.1111","volume":"26","author":[{"given":"Y. C. 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