{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:07:00Z","timestamp":1782166020309,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011970","name":"International team for implantology","doi-asserted-by":"crossref","award":["834_2012"],"award-info":[{"award-number":["834_2012"]}],"id":[{"id":"10.13039\/501100011970","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effect of submerged vs. non\u2010submerged (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>) protocols in healing outcomes of grafted marginal defects of immediate implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The second maxillary incisors were extracted bilaterally in six greyhound dogs. Bone level reduced diameter implants were installed into the extraction sockets leaving orofacial gaps of 2\u00a0mm wide. Defects were filled with Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> and covered with Bio\u2010Gide<jats:sup>\u00ae<\/jats:sup>. On the one side, the flap was advanced to fully submerge the implant, and on the other, the flap was sutured to allow NS healing. After 3\u00a0months of healing, the dogs were sacrificed and block biopsies were obtained to perform histological and morphometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All implants were clinically healthy and well integrated into bone. In the majority of the specimens, the original bone in the coronal 2\u20133\u00a0mm of the buccal crest had completely resorbed and was replaced by a regenerated bone wall consisting of Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> particles surrounded by newly formed bone. Horizontal and vertical resorption of the buccal bone resulted in \u22651\u00a0mm exposure of the implant surface in one\u2010third of implants. Minor differences existed in some aspects of hard tissue healing between submerged and <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was very little difference in healing outcomes as well as modelling of the facial bone wall between the submerged and NS protocols in relation to immediate implant placement in this dog model.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12442","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T17:25:21Z","timestamp":1422552321000},"page":"553-562","source":"Crossref","is-referenced-by-count":17,"title":["Healing of Bio\u2010Oss<sup>\u00ae<\/sup> grafted marginal gaps at implants placed into fresh extraction sockets of incisor teeth in dogs: a study on the effect of submerged vs. non\u2010submerged healing"],"prefix":"10.1111","volume":"26","author":[{"given":"Ehsan","family":"Mellati","sequence":"first","affiliation":[{"name":"Periodontics Melbourne Dental School University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Chen","sequence":"additional","affiliation":[{"name":"Periodontics Melbourne Dental School University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Davies","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Darby","sequence":"additional","affiliation":[{"name":"Periodontics Melbourne Dental School University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,17]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"387","article-title":"A 15\u2010year study of osseointegrated implants in the treatment of the edentulous jaw","volume":"10","author":"Adell R.","year":"1981","journal-title":"International Journal of Oral and Maxillofacial Surgery"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01920.x"},{"key":"e_1_2_8_4_1","first-page":"123","article-title":"The influence of Bio\u2010Oss Collagen on healing of an extraction socket: an experimental study in the dog","volume":"28","author":"Ara\u00fajo M.","year":"2008","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01705.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00726.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01317.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01315.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2002.tb00161.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02084.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01827.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070309.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844316909036699"},{"key":"e_1_2_8_14_1","first-page":"1","article-title":"Osseointegrated implants in the treatment of the edentulous jaw. 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