{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:04:34Z","timestamp":1790442274949,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008753","name":"Biomet 3i","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008753","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the impact that immediate implant placement may have on bone remodelling in comparison with adjacent sockets left to heal spontaneously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In a beagle dog model (<jats:italic>N<\/jats:italic>\u00a0=\u00a016 dogs), mandibular premolars were extracted, and implants were placed in each distal socket (test) with the corresponding mesial site left to heal undisturbed (control). Healing was assessed measuring both the vertical distance between buccal and lingual crest (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>'<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>') and the width of buccal and lingual walls at different levels. Five healing periods were evaluated. Differences between means for each variable and for each healing period between test and control were compared (<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ruskal\u2013<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>allis test; <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>riedman test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 2 and 8\u00a0weeks of healing, the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>'<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>' distance revealed significant higher values at test compared to control sites, being this difference three times higher at the end of the study (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In the test group, the width of the crest was reduced between baseline (0.37 [0.04]) and 8\u00a0weeks healing (0.13 [0.64]), demonstrating a 62% reduction of the initial width. These differences were not observed in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immediate implant placement into fresh extraction sockets may jeopardize the vertical bone remodelling of the socket. Furthermore, a tendency towards greater buccal horizontal resorption was observed in the most coronal aspect of the buccal bone crest.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12447","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T14:07:24Z","timestamp":1405606044000},"page":"1250-1255","source":"Crossref","is-referenced-by-count":30,"title":["Fresh extraction socket: spontaneous healing vs. immediate implant placement"],"prefix":"10.1111","volume":"26","author":[{"given":"Nicola","family":"Discepoli","sequence":"first","affiliation":[{"name":"Postgraduate Periodontology University Complutense of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Vignoletti","sequence":"additional","affiliation":[{"name":"Postgraduate Periodontology University Complutense of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Laino","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Universita' Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"de Sanctis","sequence":"additional","affiliation":[{"name":"Postgraduate Periodontology Universita degli Studi di Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"School of Veterinary Sciences of the University of Santiago de Compostela Lugo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Postgraduate Periodontology University Complutense of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2012.00471.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110569"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(69)90357-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00642.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00726.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01315.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02535.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12070"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01237.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00565.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01270.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01842.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02332.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00366.x"},{"key":"e_1_2_7_16_1","first-page":"1222","article-title":"Comparison of radiographic and clinical outcomes following immediate provisionalization of single\u2010tooth dental implants placed in healed alveolar ridges and extraction sockets","volume":"25","author":"Cooper L.F.","year":"2010","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_17_1","first-page":"191","article-title":"Anatomic consideration for preventive implantation","volume":"8","author":"Denissen H.W.","year":"1993","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12074"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01413.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01209.x"},{"key":"e_1_2_7_21_1","first-page":"26","article-title":"Consensus statements and recommended clinical procedures regarding the placement of implants in extraction sockets","volume":"19","author":"Hammerle C.H.","year":"2004","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.1969.tb06001.x"},{"key":"e_1_2_7_23_1","first-page":"137A","article-title":"A formaldehyde\u2013glutaraldehyde fixative of high osmolarity for use in electron microscopy","volume":"27","author":"Karnovsky M.J.","year":"1965","journal-title":"Journal of Cell Biology"},{"key":"e_1_2_7_24_1","first-page":"150","article-title":"Consensus statements and recommended clinical procedures regarding implant survival and complications","volume":"19","author":"Lang N.P.","year":"2004","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02372.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(67)90046-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01824.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12073"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01848.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01246.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01830.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01439.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01489.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01803.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01363.x"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.12447","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.12447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:30:59Z","timestamp":1696332659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.12447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,17]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/clr.12447"],"URL":"https:\/\/doi.org\/10.1111\/clr.12447","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,17]]}}}