{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:38Z","timestamp":1740124358485,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scil Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor\u20105 (rh<jats:styled-content style=\"fixed-case\">GDF<\/jats:styled-content>\u20105) induces an increased and homogenous distribution of new bone formation across the entire volume of sinus floor augmentation in 12 Goettingen Minipigs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In a randomized split\u2010mouth design, one maxillary sinus was augmented with the bone substitute \u03b2\u2010<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content>, whereas a combination of \u03b2\u2010<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content> and the osteoinductive growth factor rh<jats:styled-content style=\"fixed-case\">GDF<\/jats:styled-content>\u20105 was used on the contralateral side. To evaluate the influence of dose and time on the effectiveness of the factor, two different concentrations of rh<jats:styled-content style=\"fixed-case\">GDF<\/jats:styled-content>\u20105 (400\u00a0\u03bcg and 800\u00a0\u03bcg) and healing periods (4 and 12\u00a0weeks) were each analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 4\u00a0weeks, a homogenous gradient of bone formation could be observed for all dosage groups, with decreasing bone density from the local bone towards the sinus membrane. Both test groups, however, achieved a higher total level of bone formation compared with the control group, which was only significant in the low\u2010dose group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0184). After 12\u00a0weeks, the influence of the growth factor significantly depends on the region (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.023). In the low\u2010dose group, the new bone formation did not differ significantly within the examined regions of the graft (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.1118), suggesting a homogeneous bone formation over the entire augmentation. The gradient of the high\u2010dose group was similar to the control group with a decrease of local bone development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>rh<jats:styled-content style=\"fixed-case\">GDF<\/jats:styled-content>\u20105 delivered on a \u03b2\u2010<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content> scaffold material leads to an increase in homogeneous new bone formation across the entire volume of the sinus floor augmentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12457","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T12:46:51Z","timestamp":1405601211000},"page":"1321-1327","source":"Crossref","is-referenced-by-count":5,"title":["Increase of homogenous new bone formation using osteoinductive factor rh<scp>GDF<\/scp>\u20105 during sinus floor augmentation in Goettingen 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