{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:37:40Z","timestamp":1792179460252,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Health technology R&D Project"},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["A110266"],"award-info":[{"award-number":["A110266"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study compared the effects of <jats:italic>Escherichia<\/jats:italic>\u2010<jats:italic>coli<\/jats:italic>\u2010produced recombinant human bone morphogenetic protein 2 (Erh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102) with a biphasic calcium phosphate (<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>) carrier to those of deproteinized bovine bone in human maxillary sinus floor augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Screening for this clinical trial selected 56 sites that provided informed consent to participate, of which 46 were ultimately enrolled and 41 were finally included in the study. The sites were divided into two groups using a random\u2010number table, and the material was applied. A trephine biopsy was performed after 24\u00a0weeks, and implants wider than the biopsy site were inserted. Computed tomography and plain panoramic images were obtained immediately and then again at 24\u00a0weeks after the surgery. Radiographic images were reconstructed to allow measurement of the linear and volumetric changes. The biopsy samples were processed for histologic and histometric analyzes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All sites healed uneventfully with no complications. Radiographic analysis revealed a tendency for the volume to increase, but the difference was not statistically significant in either group. Comparison of volumetric changes between the two groups also revealed no significant difference. Moreover, none of the histometric parameters differed significantly between the groups, although different healing patterns were observed on histologic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical implications<\/jats:title><jats:p>It can be concluded that sinus augmentation with Erh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 carrying <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> carrier did not enhance bone regeneration compared to the conventional treatment using deproteinized bovine bone at 24\u00a0weeks after the surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12471","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T13:51:31Z","timestamp":1409752291000},"page":"1361-1368","source":"Crossref","is-referenced-by-count":42,"title":["Prospective randomized, controlled trial of sinus grafting using <i>Escherichia<\/i>\u2010<i>coli<\/i>\u2010produced rh<scp>BMP<\/scp>\u20102 with a biphasic calcium phosphate carrier compared to deproteinized bovine bone"],"prefix":"10.1111","volume":"26","author":[{"given":"Min\u2010Soo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Ki","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul 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