{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:01:48Z","timestamp":1754557308300},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tecnoss Dental srl"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the influence of local administration of pamidronate histomorphometrically, adsorbed on a collagenated porcine bone substitute, on extraction socket healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Two American Fox\u2010hound dogs were used within this proof\u2010of\u2010principle study. Following endodontic treatment of the distal root of the three lower premolars, the teeth were hemisected, and the mesial roots were extracted flapless. The sockets were then loosely filled, in a split\u2010mouth fashion, with a collagenated porcine bone substitute (Osteobiol Gen\u2010Os; <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>), rehydrated either with 90\u00a0mg\/ml pamidronate (Aredia<jats:sup>\u00ae<\/jats:sup>; test) or with sterile saline (control). Extraction sockets were sealed with connective tissue punches obtained from the palate and secured with sutures. After 4\u00a0months of healing, specimens containing the socket sites and remaining roots were retrieved and histomorphometrically examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histological evaluation of the sections revealed substantial differences in healing patterns. Control sites presented with various amounts of newly formed bone and no evidence of <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> inside the socket; in contrast, limited amounts of bone were observed at test sites, which were filled with <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> mainly embedded in connective tissue. Only minor differences were observed between test and control sites regarding vertical bone loss (buccal bone: \u22121.01\u00a0mm vs. \u22121.15\u00a0mm; lingual bone: \u22120.92\u00a0mm vs. \u22121.15\u00a0mm). Horizontal bone loss was nearly three times higher in control sites comparing to sites treated with pamidronate (\u22122.19\u00a0\u00b1\u00a01.81\u00a0mm vs. \u22120.80\u00a0\u00b1\u00a00.91\u00a0mm) at a level corresponding to 3\u00a0mm below the cemento\u2010enamel junction (<jats:styled-content style=\"fixed-case\">CEJ<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Local administration of pamidronate adsorbed on a collagenated porcine bone substitute in particulate form appeared to delay extraction socket healing, but may also reduce post\u2010extraction dimensional changes in terms of horizontal bone width. Additionally, pamidronate appears to obstruct resorption of the porcine bone substitute.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12483","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T05:51:01Z","timestamp":1410760261000},"page":"1135-1142","source":"Crossref","is-referenced-by-count":12,"title":["Influence of local administration of pamidronate on extraction socket healing \u2013 a histomorphometric proof\u2010of\u2010principle pre\u2010clinical <i>in vivo<\/i> evaluation"],"prefix":"10.1111","volume":"26","author":[{"given":"Kai R.","family":"Fischer","sequence":"first","affiliation":[{"name":"Department of Periodontology University Witten\/Herdecke Witten Germany"},{"name":"Periodontology Unit UCL Eastman Dental Institute London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Stavropoulos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Odontology Malm\u00f6 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