{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:51:23Z","timestamp":1790484683859,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T00:00:00Z","timestamp":1411776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This pilot randomised controlled clinical trial aimed to evaluate the feasibility and effectiveness of using a polycaprolactone (<jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content>) scaffold in fresh extraction sockets for ridge preservation. The hypothesis was that the insertion of a 3D bioresorbable <jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content> scaffold in fresh extraction sockets allowed for normal bone healing and better maintenance of ridge dimensions after 6\u00a0months as compared to extraction sockets without the scaffold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Thirteen patients were randomised to either the test group (<jats:italic>N<\/jats:italic>\u00a0=\u00a06) where a <jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content> scaffold was inserted in the tooth socket after extraction or the control group (<jats:italic>N<\/jats:italic>\u00a0=\u00a07) where no space filler was used. Alveolar ridge height and width measurements were made at baseline and 6\u00a0months post\u2010extraction, for the evaluation of bone resorption. At 6\u00a0months, a core of bone was trephined out from the healed ridge for microcomputed tomographic (micro <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) and histological analyses, immediately before Stage I dental implant surgery. Stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> dental implant surgery was performed 4\u20136\u00a0months later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was less vertical ridge resorption in the test group compared to the control group, and the difference was statistically significant in the mesio\u2010buccal aspect (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Micro <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and histological observations showed mainly mineralised bone formation in both groups, except for one specimen in the test group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The insertion of a 3D bioresorbable <jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content> scaffold in fresh extraction sockets allowed for normal bone healing, and there was better maintenance of ridge height after 6\u00a0months as compared to extraction sockets without the scaffold.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12486","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T08:57:11Z","timestamp":1411808231000},"page":"271-277","source":"Crossref","is-referenced-by-count":120,"title":["Novel 3<scp>D<\/scp> polycaprolactone scaffold for ridge preservation \u2013 a pilot randomised controlled clinical 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