{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:07:52Z","timestamp":1783512472030,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T00:00:00Z","timestamp":1411776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ITI foundation","award":["821-2012"],"award-info":[{"award-number":["821-2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this experiment was to test whether or not a synthetic bone substitute (<jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>) was more effective than a polyethylene glycol hydrogel as a carrier material for bone morphogenetic protein\u20102 (<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102) when attempting to regenerate bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Two identical, box\u2010type dehiscence defects (4\u00a0\u00d7\u00a04\u00a0mm buccolingually and apicocoronally, and 8\u00a0mm mesiodistally) were surgically prepared on buccal sides of the left and right edentulous ridge in five beagle dogs. Following implant placement, the defects either received (i) no graft, (ii) <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>+hydrogel, (iii) <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 loaded hydrogel, and (iv) <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\u2010loaded <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>+hydrogel. The animals were euthanized at 8\u00a0weeks postsurgery. Radiographic and histomorphometric analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The hydrogel alone was not able to stabilize the grafted bone particles at 8\u00a0weeks, and <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>+hydrogel group did not significantly differ from the control group in all volumetric measurements. On the other hand, extensively regenerated new bone was connected with most of the remaining <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content> particles in the <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 groups. The <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 groups exhibited significantly greater new bone formation (10.65\u00a0mm<jats:sup>3<\/jats:sup> and 1.47\u00a0mm<jats:sup>2<\/jats:sup> in the <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\u2010loaded hydrogel group; 14.17\u00a0mm<jats:sup>3<\/jats:sup> and 0.93\u00a0mm<jats:sup>2<\/jats:sup> in the <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\u2010loaded <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>+hydrogel) than non\u2010<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 groups (1.27\u00a0mm<jats:sup>3<\/jats:sup> and 0.00\u00a0mm<jats:sup>2<\/jats:sup> in the control group; 2.01\u00a0mm<jats:sup>3<\/jats:sup> and 0.19\u00a0mm<jats:sup>2<\/jats:sup> in the <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>+hydrogel group) in volumetric and histomorphometric analyses (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). However, there were no significant differences between both <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 could yield enhanced bone regeneration in the critical\u2010size peri\u2010implant defects regardless of whether <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content> or hydrogel is used for preloading, although the outcomes seem to be more reproducible with <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 preloaded on <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12491","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T08:59:32Z","timestamp":1411808372000},"page":"1456-1465","source":"Crossref","is-referenced-by-count":21,"title":["The efficacy of <scp>BMP<\/scp>\u20102 preloaded on bone substitute or hydrogel for bone regeneration at peri\u2010implant defects in dogs"],"prefix":"10.1111","volume":"26","author":[{"given":"Ui\u2010Won","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u2010Kyeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Department of Fixed and Removable Prosthodontics and Dental Material Science Dental School University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph H. 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