{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:06:11Z","timestamp":1789203971430,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Brazilian agency Fapesp (Funda\u00e7\u00e3o de amparo a pesquisa do estado de S\u00e3o Paulo)","award":["2012\/16939-1"],"award-info":[{"award-number":["2012\/16939-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of the long\u2010term administration of alendronate on the mechanical properties of the basal bone and on osseointegration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>One hundred and sixty female rats were randomly allocated into two equally sized groups: the control (<jats:styled-content style=\"fixed-case\">CTL<\/jats:styled-content>) group, which received the subcutaneous administration of saline solution, and the alendronate (<jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content>) group, which received the subcutaneous administration of alendronate (1\u00a0mg\/kg\/week). After 120\u00a0days of these therapies, one implant was placed in each rat tibia. Ten animals in each group were euthanized at 5, 10, 15, 20, 25, 30, 45, or 60\u00a0days after surgery. The tibias with implants evaluated regarding the removal torque, bone\u2010implant contact (<jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content>), the bone area fraction occupancy (<jats:styled-content style=\"fixed-case\">BAFO<\/jats:styled-content>), and Ca\/P ratio. The femurs were evaluated regarding bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) and using mechanical tests to evaluate the maximal force of fracture, stiffness, and tenacity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content> group presented statistically significant higher <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> (all periods except 15\u00a0days), maximal force of fracture (at 20, 30, and 45\u00a0days), tenacity (at 10, 20, 30, and 45\u00a0days), stiffness (45\u00a0days), removal torque (at 20, 25 and 30 days), <jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content> (at 20 and 60\u00a0days), and <jats:styled-content style=\"fixed-case\">BAFO<\/jats:styled-content> (at 20, 30, and 45\u00a0days) than the <jats:styled-content style=\"fixed-case\">CTL<\/jats:styled-content> group. No differences were found between the groups regarding the Ca\/P ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Previous long\u2010term therapy with alendronate caused an increase in the <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>, maximal force of fracture of the bone without changing the inorganic composition and elastic deformability of this tissue. Furthermore, the <jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content> therapy enhanced osseointegration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12492","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T04:30:00Z","timestamp":1413433800000},"page":"1466-1475","source":"Crossref","is-referenced-by-count":16,"title":["Effects of the long\u2010term administration of alendronate on the mechanical properties of the basal bone and on osseointegration"],"prefix":"10.1111","volume":"26","author":[{"given":"Mario Henrique A.","family":"Verzola","sequence":"first","affiliation":[{"name":"FOAr\u2010UNESP Araraquara Dental School University Estadual Paulista Araraquara Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Frizzera","sequence":"additional","affiliation":[{"name":"FOAr\u2010UNESP Araraquara Dental School University Estadual Paulista Araraquara Brazil"},{"name":"Integrated College Esp\u00edrito Santentes FAESA Dental School Vit\u00f3ria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme J. 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