{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:44:40Z","timestamp":1787161480296,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,28]],"date-time":"2014-12-28T00:00:00Z","timestamp":1419724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Considering the low rate of deproteinized bovine bone (\n                      <jats:styled-content style=\"fixed-case\">DBB<\/jats:styled-content>\n                      ) graft resorption\n                      <jats:italic>in vivo<\/jats:italic>\n                      and vitro, the aim of this study was to investigate, through an immunohistochemical method,\n                      <jats:styled-content style=\"fixed-case\">DBB<\/jats:styled-content>\n                      remodeling patterns in human.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Socket preservation, a highly documented and affirmed technique, was selected as the best\n                      <jats:italic>in vitro<\/jats:italic>\n                      model to analyze\n                      <jats:styled-content style=\"fixed-case\">DBB<\/jats:styled-content>\n                      effect on bone remodeling. Following premolar extraction (T0), 20 patients were randomized into two treatment groups. In the test group (t), the alveolar sockets were grafted with\n                      <jats:styled-content style=\"fixed-case\">DBB<\/jats:styled-content>\n                      , while in the control group (c) no bone graft was applied and the alveolar sockets were left to heal spontaneously. After 5\u00a0months, a re\u2010entry procedure was performed, and one implant was placed according to manufacturer's protocols (T1). Bone biopsies were harvested for each patient both at T0 and at T1. On the bone samples, immunohistochemical investigations were performed to analyze\n                      <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\n                      \u20102,\n                      <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\n                      \u20107,\n                      <jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20106,\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      \u2010\u03b1 expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bone morphogenetic proteins were more expressed in the control group than in the test group (\n                      <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\n                      \u20102:\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001;\n                      <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\n                      \u20107:\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.017), while\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      \u2010\u03b1 value was larger in the test group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001); no statistically significant differences were observed for the other markers. When considering time as the main variable, statistically significant differences were found for\n                      <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\n                      \u20102 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001),\n                      <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\n                      \u20107 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001),\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20106 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001),\n                      <jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), and\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      \u2010\u03b1 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Significant interaction between groups and time was found for\n                      <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\n                      \u20102 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001),\n                      <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\n                      \u20107 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001),\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      \u2010\u03b1 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Deproteinized bovine bone guarantees the activity of bone remodeling processes in human extraction socket at 5\u00a0months of healing, bringing to a higher expression of anabolic and catabolic bone markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.12535","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T07:14:18Z","timestamp":1419837258000},"page":"295-302","source":"Crossref","is-referenced-by-count":22,"title":["Deproteinized bovine bone remodeling pattern in alveolar socket: a clinical immunohistological evaluation"],"prefix":"10.1111","volume":"27","author":[{"given":"Stefano","family":"Milani","sequence":"first","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dal Pozzo","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Rasperini","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences Universit\u00e0 degli Studi di Milano Milan Italy"},{"name":"Foundation IRCCS Ca' Granda Polyclinic Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiarella","family":"Sforza","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Dellavia","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01881.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01854.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01920.x"},{"key":"e_1_2_5_5_1","first-page":"123","article-title":"The influence of Bio\u2010Oss\u00ae collagen on healing of an extraction socket\u2010An experimental study in the dog","volume":"28","author":"Ara\u00f9jo M.G.","year":"2008","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2010.10.017"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01400.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.4.414"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1997.080206.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00209.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.140201.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01565.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3180de4c5f"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1982.tb00172.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2006.tb00409.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12112"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02073.x"},{"key":"e_1_2_5_18_1","first-page":"1013","article-title":"Bone grafting materials for dental applications: a practical guide","volume":"18","author":"Gross J.","year":"1997","journal-title":"Compendium"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02148.x"},{"key":"e_1_2_5_20_1","first-page":"282","volume-title":"Comprehensive Biomaterials: Online Version","author":"Hollinger J.O.","year":"2011"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00161.x"},{"key":"e_1_2_5_22_1","first-page":"1","article-title":"Aspects of bone healing and bone substitute incorporation. An experimental study in rabbit skull bone defects","volume":"84","author":"Isaksson S.","year":"1992","journal-title":"Swedish Dental Journal Supplement"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ID.0000127522.14067.11"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00319-7"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01918.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01939.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02462.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0905-7161.2003.00952.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00542.x"},{"key":"e_1_2_5_30_1","first-page":"265","article-title":"Socket grafting in the posterior maxilla reduces the need for sinus augmentation","volume":"30","author":"Rasperini G.","year":"2010","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.140316.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100297"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01520.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.01099.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01246.x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.7.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2004.10.023"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.12535","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.12535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T03:42:41Z","timestamp":1695699761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.12535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,28]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/clr.12535"],"URL":"https:\/\/doi.org\/10.1111\/clr.12535","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,28]]}}}