{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:04:22Z","timestamp":1767164662016,"version":"build-2238731810"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n The aim of the study was to compare the effects of porcine xenografts (\n MP<\/jats:styled-content>\n 3\n \u00ae<\/jats:sup>\n ) with or without pamindronate for the healing of small and large defects of postextraction sockets.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n Six beagle dogs were used in the study; second premolars and first molars of the mandible were extracted, small defects (\n SD<\/jats:styled-content>\n ) and large defects (\n LD<\/jats:styled-content>\n ) were identified. Each defect was measured and randomly filled as follows:\n SC<\/jats:styled-content>\n (small control defects filled with\n MP<\/jats:styled-content>\n 3\n \u00ae<\/jats:sup>\n alone),\n ST<\/jats:styled-content>\n (small test defects filled with\n MP<\/jats:styled-content>\n 3\n \u00ae<\/jats:sup>\n modified with pamindronate),\n LC<\/jats:styled-content>\n (large control defects filled with\n MP<\/jats:styled-content>\n 3\n \u00ae<\/jats:sup>\n alone),\n LT<\/jats:styled-content>\n (large test defects filled with\n MP<\/jats:styled-content>\n 3\n \u00ae<\/jats:sup>\n modified with pamindronate). After 4 and 8\u00a0weeks, the animals were euthanized and the percentages of new bone formation (\n NB<\/jats:styled-content>\n ), residual graft (\n RG<\/jats:styled-content>\n ) and connective tissue (\n CT<\/jats:styled-content>\n ) were analysed by histology and histomorphometry of undecalcified samples.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After 4\u00a0weeks,\n NB<\/jats:styled-content>\n formation was higher for\n ST<\/jats:styled-content>\n compared to all groups and for\n LT<\/jats:styled-content>\n compared to\n LC<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0<\u00a00.05);\n RG<\/jats:styled-content>\n was significantly higher in both control groups compared to tests (\n P<\/jats:italic>\n \u00a0<\u00a00.05); and\n CT<\/jats:styled-content>\n was higher in large defects (\n LC<\/jats:styled-content>\n and\n LT<\/jats:styled-content>\n ) compared to small defects. After 8\u00a0weeks,\n NB<\/jats:styled-content>\n formation was higher for test groups (\n ST<\/jats:styled-content>\n and\n LT<\/jats:styled-content>\n ) compared to controls (\n P<\/jats:italic>\n \u00a0<\u00a00.05);\n RG<\/jats:styled-content>\n was significantly higher in both control groups compared to tests (\n P<\/jats:italic>\n \u00a0<\u00a00.05); and\n CT<\/jats:styled-content>\n was higher in large defects (\n LC<\/jats:styled-content>\n and\n LT<\/jats:styled-content>\n ) compared to small defects (\n P<\/jats:italic>\n \u00a0<\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Within the limitations of this experimental study, the findings suggest that porcine xenografts modified with pamindronate favours the new bone formation and increased the porcine xenograft substitution\/replacement after 4 and 8\u00a0weeks of healing.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/clr.12550","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T00:00:02Z","timestamp":1422662402000},"page":"149-155","source":"Crossref","is-referenced-by-count":6,"title":["RETRACTED: Xenografts Supplemented with Pamindronate placed in postextraction sockets to avoid crestal bone resorption. Experimental study in Fox hound dogs"],"prefix":"10.1111","volume":"27","author":[{"given":"Naroa","family":"Lozano\u2010Carrascal","sequence":"first","affiliation":[{"name":"General Dentistry International University of Catalonia Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-0509","authenticated-orcid":false,"given":"Rafael arcesio","family":"Delgado\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Digital Technology School of Dental Medicine Stony Brook University Stony Brook NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Gargallo\u2010Albiol","sequence":"additional","affiliation":[{"name":"Implant Dentistry International University of Catalonia Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Eduardo","family":"Mat\u00e9\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Restorative Dentistry Faculty of Medicine and Dentistry University of Murcia Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Hernandez Alfaro","sequence":"additional","affiliation":[{"name":"Implant Dentistry International University of Catalonia Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-5416","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Calvo\u2010Guirado","sequence":"additional","affiliation":[{"name":"General & Implant Dentistry Faculty of Medicine and Dentistry University of Murcia Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"902","article-title":"Clinical and histologic healing of human extraction sockets filled 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