{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:18:56Z","timestamp":1790108336701,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to evaluate implant survival and primary stability parameters in patients with diabetes with different levels of glycosylated hemoglobin Alc (HbA1c) treated with immediate placement and provisionalization of implant\u2010supported, single\u2010tooth replacements over 2\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Eighty\u2010five patients were divided into three groups according to their HbA1c levels: 33 patients in Group 1 (&lt;6, control group); 30 patients in Group 2 (6.1\u20138); and 22 patients in Group 3 (8.1\u201310). Each patient received one\u2010one\u2010piece implant in the anterior zone of the upper maxillary. The implant survival rate was analyzed for each group, together with three variables to evaluate the general state of peri\u2010implant health: probe depth, bleeding on probing, marginal bone loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Marginal bone loss increased in relation with higher HbA1c levels. For marginal bone loss in Group 1, mean resorption values ranged from 0.51 after 6\u00a0months to 0.72 after 2\u00a0years in comparison with respective values of 1.33 and 1.92 in Group 3. This pattern was repeated for bleeding on probing, both parameters showing significant differences between groups. For bleeding on probing, mean bleeding levels varied from 0.36 in Group I at 6\u00a0months after implant placement, to 0.59 in Group 3 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.041 between the three groups). Peri\u2010implant pocket depth showed the same tendency to increase in relation to HbA1C but differences between groups did not reach statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with diabetes can receive implant\u2010based treatments with immediate loading safely, providing they present moderate HbA1c values.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12552","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T05:06:03Z","timestamp":1422335163000},"page":"156-161","source":"Crossref","is-referenced-by-count":78,"title":["Peri\u2010implant evaluation of immediately loaded implants placed in esthetic zone in patients with diabetes mellitus type 2: a two\u2010year study"],"prefix":"10.1111","volume":"27","author":[{"given":"Antonio","family":"Aguilar\u2010Salvatierra","sequence":"first","affiliation":[{"name":"Department of Pharmacological Research in Dentistry Faculty of Dentistry University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-5416","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Calvo\u2010Guirado","sequence":"additional","affiliation":[{"name":"Department of Implant Dentistry Master of Implant Dentistry and Biomaterials School of Medicine and Dentistry University of Murcia Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximino","family":"Gonz\u00e1lez\u2010Jaranay","sequence":"additional","affiliation":[{"name":"Department of Periodontology Master of Periodontology and Implant Dentistry Faculty of Dentistry University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Moreu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Master of Periodontology and Implant Dentistry Faculty of Dentistry University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-0509","authenticated-orcid":false,"given":"Rafael Arcesio","family":"Delgado\u2010Ruiz","sequence":"additional","affiliation":[{"name":"School of Dental Medicine Stony Brook University Stony Brook NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"G\u00f3mez\u2010Moreno","sequence":"additional","affiliation":[{"name":"Department of Special Care in Dentistry, Pharmacological Research in Dentistry Master of Periodontology and Implant Dentistry Faculty of Dentistry University of Granada Granada 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