{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:23:46Z","timestamp":1789543426961,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T00:00:00Z","timestamp":1424044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Departments of Oral Surgery, Periodontology, and Fixed Prosthodontics at the University of Bern"},{"name":"ITI Foundation for the Promotion of Implant Dentistry","award":["637-2009"],"award-info":[{"award-number":["637-2009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>To assess a selection of host\u2010derived biomarkers in peri\u2010implant sulcus fluid (PISF<\/jats:styled-content>) and gingival crevicular fluid (GCF<\/jats:styled-content>) from adjacent teeth 10\u00a0years following implant placement.<\/jats:p><\/jats:sec>Material and methods<\/jats:title>Peri\u2010implant sulcus fluid and GCF<\/jats:styled-content> samples obtained from the deepest sites of 504 implants and 493 adjacent teeth were analysed for levels of interleukin (IL<\/jats:styled-content>)\u20101\u03b2, matrix metalloproteinase (MMP<\/jats:styled-content>)\u20103, MMP<\/jats:styled-content>\u20108, MMP<\/jats:styled-content>\u20101, and MMP<\/jats:styled-content>\u20101 bound to tissue inhibitor of MMP<\/jats:styled-content> (TIMP<\/jats:styled-content>)\u20101 (MMP<\/jats:styled-content>\u20101\/TIMP<\/jats:styled-content>\u20101) by enzyme\u2010linked immunosorbent assay (ELISA<\/jats:styled-content>) technique.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, MMP<\/jats:styled-content>\u20108 was detected in 90% of the sites. In more than 50% of the sites, IL<\/jats:styled-content>\u20101\u03b2 was identified while in 30% of the sites MMP<\/jats:styled-content>\u20101, MMP<\/jats:styled-content>\u20101\/TIMP<\/jats:styled-content>\u20101 and MMP<\/jats:styled-content>\u20103 were found over the detection level. Increased biomarkers levels from PISF<\/jats:styled-content> and GCF<\/jats:styled-content> were positively correlated (r<\/jats:italic>\u00a0=\u00a00.375\u20130.702; P<\/jats:italic>\u00a0<\u00a00.001). However, no qualitative and quantitative differences were found between PISF<\/jats:styled-content> and GCF<\/jats:styled-content>. The levels of MMP<\/jats:styled-content>\u20101 were negatively correlated with those of MMP<\/jats:styled-content>\u20101\/TIMP<\/jats:styled-content>\u20101 at implants (r<\/jats:italic>\u00a0=\u00a0\u22120.644; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001). Median MMP<\/jats:styled-content>\u20101 levels at implants were high (5.17\u00a0pg\/site) in subjects with severe chronic periodontitis and low in patients with mild\u2010to\u2010moderate chronic periodontitis (0\u00a0pg\/site; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.026) or gingivitis (0\u00a0pg\/site; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.034). Levels of IL<\/jats:styled-content>\u20101\u03b2 were found to be different in GCF<\/jats:styled-content> according to the periodontal conditions (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.001) with the highest level found in mild\u2010to\u2010moderate periodontitis (6.2\u00a0pg\/site). Clinical attachment levels at implants demonstrated an inverse correlation with MMP<\/jats:styled-content>\u20101\/TIMP<\/jats:styled-content>\u20101 (r<\/jats:italic>\u00a0=\u00a0\u22120.147; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Increased levels of MMP<\/jats:styled-content>\u20108 and IL<\/jats:styled-content>\u20101\u03b2 in PISF<\/jats:styled-content> or GCF<\/jats:styled-content> may be associated with inflammation around teeth and implants while lower levels of MMP<\/jats:styled-content>\u20101\/TIMP<\/jats:styled-content>\u20101 may be an indicator of disease progression around implants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12566","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T06:38:54Z","timestamp":1424068734000},"page":"211-217","source":"Crossref","is-referenced-by-count":48,"title":["Host\u2010derived biomarkers at teeth and implants in partially edentulous patients. 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