{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:13:01Z","timestamp":1780625581067,"version":"3.54.1"},"reference-count":79,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ITI Foundation","award":["Grant Nr. 706_2010"],"award-info":[{"award-number":["Grant Nr. 706_2010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate ridge preservation after ridge splitting with simultaneous implant placement and guided bone regeneration (GBR) in a miniature pig model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In miniature pigs, the mandibular premolars and first molars were extracted together with removal of the interdental and buccal bone. Three months later, ridge splitting and expansion of the buccal plate were performed with simultaneous placement of two titanium implants per quadrant. On the test side, access by a mucoperiosteal flap followed by GBR with a biphasic calcium phosphate and a collagen membrane was performed. On the contralateral control side, a mucosal flap (MF), leaving the periosteum attached to the buccal bone, was elevated. After healing periods of 6 and 12\u00a0weeks, eight and four animals, respectively, were sacrificed for histological and histometric evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the MF group, all 16 implants were osseointegrated, while in the GBR group, one bone fracture occurred, and six of 16 implants were lost. After 6\u00a0weeks, significantly higher bone crest levels were found for the GBR group than for the MF group both buccally and lingually (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and buccal bone thickness was greater in the GBR group than in the MF group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 at the implant shoulder [IS]). After 12\u00a0weeks, bone was significantly higher in the GBR group compared to the MF group. Furthermore, buccal bone thickness in the GBR group was 0.93, 4.5, and 5.94\u00a0mm at, and 2 and 4\u00a0mm apical to the IS, respectively. The corresponding values in the MF group were greatly reduced (0, 0.21, and 2.56\u00a0mm). Bone loss on the buccal side compared to the lingual side was significantly greater only in the MF group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this ridge expansion model in miniature pigs, the buccal bone volume was significantly better preserved with GBR when compared to a mucosal access flap, provided that soft tissue healing occurred complication free.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12574","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T09:08:49Z","timestamp":1425892129000},"source":"Crossref","is-referenced-by-count":5,"title":["Ridge preservation after ridge expansion with simultaneous guided bone regeneration: a preclinical study"],"prefix":"10.1111","volume":"27","author":[{"given":"Andres","family":"Stricker","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Freiburg Freiburg Germany"},{"name":"Center of Implantology Periodontology and 3D Head\u2010 and Neck Diagnostics Konstanz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Fleiner","sequence":"additional","affiliation":[{"name":"Center of Implantology Periodontology and 3D Head\u2010 and Neck Diagnostics Konstanz Germany"},{"name":"Oral Imaging Center Faculty of Medicine Katholieke Universiteit Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"St\u00fcbinger","sequence":"additional","affiliation":[{"name":"Musculoskeletal Research Unit Equine Hospital Vetsuisse Faculty ZH University of Zurich Zurich Switzerland"},{"name":"Center of Applied Biotechnology and Molecular Medicine (CABMM) Vetsuisse Faculty University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Fleiner","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Buser","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Stomatology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter D.","family":"Bosshardt","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Stomatology School of Dental Medicine University of Bern Bern Switzerland"},{"name":"Robert K. 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