{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T21:49:44Z","timestamp":1775339384620,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinic for Fixed and Removable Prosthodontics and Dental Material Science, University of Zurich"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim was to test whether or not the marginal bone\u2010level alterations of loaded zirconia implants are similar to the bone\u2010level alterations of a grade 4 titanium one\u2010piece dental implant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In six dogs, all premolars and the first molars were extracted in the mandible. Four months later, three zirconia implants (<jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ZD<\/jats:styled-content>) and a control titanium one\u2010piece (<jats:styled-content style=\"fixed-case\">STM<\/jats:styled-content>) implant were randomly placed in each hemimandible and left for transmucosal healing (baseline). Six months later, <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> crowns were cemented. Sacrifice was scheduled at 6\u2010month postloading. Digital X\u2010rays were taken at implant placement, crowns insertion, and sacrifice. Marginal bone\u2010level alterations were calculated, and intra\u2010 and intergroup comparisons performed adjusted by confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Implants were successfully placed. Until crown insertion, two implants were fractured (one <jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>, one <jats:styled-content style=\"fixed-case\">ZD<\/jats:styled-content>). At sacrifice, 5 more implants were (partly) fractured (one <jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content>, four <jats:styled-content style=\"fixed-case\">ZD<\/jats:styled-content>), and one lost osseointegration (<jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>). No decementation of crowns occurred. All implant systems demonstrated a statistically significant (except <jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>) loss of marginal bone between baseline and crown insertion ranging from 0.29\u00a0mm (<jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>;<jats:italic> P\u00a0<\/jats:italic>=\u00a00.116) to 0.80\u00a0mm (<jats:styled-content style=\"fixed-case\">ZD<\/jats:styled-content>;<jats:italic> P<\/jats:italic>\u00a0=\u00a00.013). The estimated marginal bone loss between baseline and 6\u00a0months of loading ranged between 0.19\u00a0mm (<jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content>) and 1.11\u00a0mm (<jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>), being statistically significant for <jats:styled-content style=\"fixed-case\">STM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content> only (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The changes in marginal bone levels were statistically significantly different between zirconia implants and control implants (<jats:styled-content style=\"fixed-case\">STM<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">BPI <\/jats:styled-content><jats:italic>P<\/jats:italic>\u00a0=\u00a00.007; vs. <jats:styled-content style=\"fixed-case\">VC <\/jats:styled-content><jats:italic>P<\/jats:italic>\u00a0=\u00a00.001; vs. <jats:styled-content style=\"fixed-case\">ZD <\/jats:styled-content><jats:italic>P<\/jats:italic>\u00a0=\u00a00.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Zirconia implants were more prone to fracture prior to and after loading with implant\u2010supported crowns compared to titanium implants. Individual differences and variability in the extent of the bone\u2010level changes during the 12\u2010month study period were found between the different implant types and materials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12595","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T23:01:48Z","timestamp":1428706908000},"page":"412-420","source":"Crossref","is-referenced-by-count":12,"title":["Marginal bone\u2010level alterations of loaded zirconia and titanium dental implants: an experimental study in the dog mandible"],"prefix":"10.1111","volume":"27","author":[{"given":"Daniel S.","family":"Thoma","sequence":"first","affiliation":[{"name":"Clinic for Fixed and Removable Prosthodontics and Dental Material Science University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran I.","family":"Benic","sequence":"additional","affiliation":[{"name":"Clinic for Fixed and Removable Prosthodontics and Dental Material Science University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Santiago de Compostela Lugo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Kohal","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Albert\u2010Ludwigs\u2010University Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Sanz Martin","sequence":"additional","affiliation":[{"name":"Universidad Complutense Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio G.","family":"Cantalapiedra","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Santiago de Compostela Lugo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph H. 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