{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:05:06Z","timestamp":1767978306321,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF\u20102014R1A1A1A05002953"],"award-info":[{"award-number":["NRF\u20102014R1A1A1A05002953"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to elucidate the efficacy of bone regeneration at the early stage of healing in rabbit sinuses grafted with a biphasic calcium phosphate (<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>) carrier soaked in a high concentration of recombinant human bone morphogenetic protein\u20102 (rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Both maxillary sinuses of eight male rabbits were used. The sinus on one side (assigned randomly) was grafted with <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> loaded with rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 (1.5\u00a0mg\/ml; test group) using a soaking method, while the other was grafted with saline\u2010soaked <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> (control group). After a 2\u2010week healing period, the sinuses were analyzed by micro\u2010computed tomography and histomorphometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total augmented area and soft tissue space were significantly larger in the test group than in the control group, whereas the opposite was true for the area of residual material and newly formed bone. Most of the new bone in the test group was localized to the Schneiderian membrane (<jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>), while very little bone formation was observed in the window and center regions of the sinus. New bone was distributed evenly in the control group sinuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of this study, it appeared that application of a high concentration of rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 soaked onto a <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> carrier inhibited bone regeneration from the pristine bone and increased soft tissue swelling and inflammatory response at the early healing stage of sinus augmentation, although osteoinductive potential was found along the <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12603","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T08:06:53Z","timestamp":1429517213000},"source":"Crossref","is-referenced-by-count":18,"title":["A high concentration of recombinant human bone morphogenetic protein\u20102 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