{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:24:22Z","timestamp":1766157862164},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"RLS Global AB, Gothenburg, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the adjunctive clinical effects of a chloramine to non\u2010surgical treatment of peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Eighteen individuals diagnosed with peri\u2010implantitis (clinical signs of inflammation and progressive bone loss) on at least two implants were included. Clinical variables; plaque accumulation (Pl), probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) and bleeding on probing (BoP), were recorded at baseline and at 3\u2010month follow\u2010up. Primary clinical efficacy variable was the change in the number of sites with BoP. The implants were randomized into two different treatment groups: test and control. Both implants received supra\u2010 and submucosal debridement by ultrasonic instrumentation supplemented with hand instruments. The implants assigned to the test group first received local applications of a chloramine gel (Perisolv<jats:sup>\u2122<\/jats:sup>; <jats:styled-content style=\"fixed-case\">RLS<\/jats:styled-content> Global <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>, Gothenburg, Sweden) followed by mechanical instrumentation. The oral hygiene was checked at 6\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 3\u00a0months, implants of both groups showed statistically significant reduction (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in the number of BoP\u2010positive sites compared with baseline. The reduction of BoP\u2010positive sites in the test group changed from 0.97 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u00a0\u00b1\u00a00.12) to 0.38 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u00a0\u00b1\u00a00.46), and in the control group from 0.97 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u00a0\u00b1\u00a00.12) to 0.31 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u00a0\u00b1\u00a00.42). Between\u2010group comparisons revealed no statistically significant differences at baseline and after 3\u00a0months, for BoP or any of the other variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the present randomized clinical trial of peri\u2010implantitis therapy; non\u2010surgical mechanical debridement with adjunctive use of a chloramine is equally effective in the reduction of mucosal inflammation as conventional non\u2010surgical mechanical debridement up to 3\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12612","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T17:00:29Z","timestamp":1432746029000},"page":"43-48","source":"Crossref","is-referenced-by-count":28,"title":["Treatment of peri\u2010implantitis: clinical outcome of chloramine as an adjunctive to non\u2010surgical therapy, a randomized clinical trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Ann\u2010Marie","family":"Roos\u2010Jans\u00e5ker","sequence":"first","affiliation":[{"name":"Department of Periodontology Public Dental Health Service Kristianstad Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrica S.","family":"Almh\u00f6jd","sequence":"additional","affiliation":[{"name":"Department of Cariology Institute of Odontology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Jansson","sequence":"additional","affiliation":[{"name":"Oral Health Centre of Expertise in Eastern Norway Oslo Norway"},{"name":"Department of Periodontology Centre for Oral Health Sciences Malm\u00f6 University Malm\u00f6 Sweden"},{"name":"Center for Oral Health Department of Natural Science and Biomedicine School of Health Sciences J\u00f6nk\u00f6ping University J\u00f6nk\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(81)80077-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01309.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1991.020206.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2004.06.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/000163599428751"},{"key":"e_1_2_7_7_1","first-page":"S21","article-title":"Treatment of peri\u2010implantitis: what interventions are effective? 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