{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:00Z","timestamp":1787014020035,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"International Team for Implantology (ITI) Foundation","award":["1000_2014"],"award-info":[{"award-number":["1000_2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n Since the original description of osteoinduction in the early 20th century, the study and development of innovative biomaterials has emerged. Recently, novel synthetic bone grafts have been reported with potential to form ectopic bone\n in\u00a0vivo<\/jats:italic>\n . However, their full characterization in comparison with other leading bone grafts has not been investigated. The aim of this study was to determine the osteoinductive potential of bone grafts by comparing autogenous bone grafts, demineralized freeze\u2010dried bone allografts (\n DFDBA<\/jats:styled-content>\n ), a commonly utilized natural bone mineral (\n NBM<\/jats:styled-content>\n ) from bovine origin (Bio\u2010Oss), and a newly developed biphasic calcium phosphate (\n BCP<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n Grafts were compared\n in\u00a0vitro<\/jats:italic>\n for their ability to stimulate bone marrow stromal cell (\n BMSC<\/jats:styled-content>\n ) migration, proliferation, and differentiation as assessed by quantitative real\u2010time\n PCR<\/jats:styled-content>\n for genes coding for bone markers including Runx2, collagen I, and osteocalcin. Furthermore, bone grafts were implanted in the calf muscle of 12 beagle dogs to determine their potential to form ectopic bone\n in\u00a0vivo<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n in\u00a0vitro<\/jats:italic>\n results demonstrate that both autografts and\n DFDBA<\/jats:styled-content>\n show potential for cell recruitment, whereas only autografts and\n BCP<\/jats:styled-content>\n demonstrated the ability to differentiate\n BMSC<\/jats:styled-content>\n s toward the osteoblast lineage. The\n in\u00a0vivo<\/jats:italic>\n ectopic bone model demonstrated that while\n NBM<\/jats:styled-content>\n particles were not osteoinductive and autogenous bone grafts were resorbed quickly\n in\u00a0vivo<\/jats:italic>\n , ectopic bone formation was reported in\n DFDBA<\/jats:styled-content>\n and in synthetic\n BCP<\/jats:styled-content>\n grafts.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The modifications in nanotopography and chemical composition of the newly developed\n BCP<\/jats:styled-content>\n bone grafts significantly promoted ectopic bone formation confirming their osteoinductive potential. In conclusion, the results from this study provide evidence that synthetic bone grafts not only serve as a three\u2010dimensional scaffold but are also able to promote osteoinduction.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/clr.12647","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T01:05:35Z","timestamp":1438304735000},"page":"668-675","source":"Crossref","is-referenced-by-count":86,"title":["Osteoinductive potential of a novel biphasic calcium phosphate bone graft in comparison with autographs, xenografts, and\n DFDBA<\/scp>"],"prefix":"10.1111","volume":"27","author":[{"given":"Richard J.","family":"Miron","sequence":"first","affiliation":[{"name":"Facult\u00e9 de Medecine Dentaire Pavillon de M\u00e9decine Dentaire Universit\u00e9 Laval Qu\u00e9bec City QC Canada"},{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"},{"name":"Department of Oral Surgery and Stomatology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Shuang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter D.","family":"Bosshardt","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"},{"name":"Department of Oral Surgery and Stomatology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern Switzerland"},{"name":"Department of Oral Surgery and Stomatology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Buser","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Stomatology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatiha","family":"Chandad","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Medecine Dentaire Pavillon de M\u00e9decine Dentaire Universit\u00e9 Laval Qu\u00e9bec City QC 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