{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:41:08Z","timestamp":1789594868231,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health & Medical Research Council of Australia","award":["APP1056633"],"award-info":[{"award-number":["APP1056633"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To histomorphometrically compare the use of collagen\u2010stabilized anorganic bovine bone (<jats:styled-content style=\"fixed-case\">ABBM<\/jats:styled-content>\u2010C) (test) to anorganic bovine bone\u00a0+\u00a0autogenous bone (<jats:styled-content style=\"fixed-case\">ABBM<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>) (control) in maxillary sinus augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Nine sheep underwent bilateral sinus augmentation. Each sinus was randomized to receive either control or test bone graft. Three animals were sacrificed at 8\u00a0weeks, and six animals were sacrificed at 16\u00a0weeks post\u2010grafting. The 18 sinuses were processed for histomorphometry, which assessed the area fraction of new bone (%<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content>), residual graft (%<jats:styled-content style=\"fixed-case\">RG<\/jats:styled-content>) and soft tissue components (% <jats:styled-content style=\"fixed-case\">STM<\/jats:styled-content>), as well as graft particle osseointegration (% <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content>), within three zones equally distributed from the augmented sinus floor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At week 16, a significant increase in %<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content> was evident across all three zones in the control group when compared to week 8. A significantly greater %<jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content> was evident in the control group when compared to the test group in zones 2 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and 3 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). There was a significant increase in %<jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> in week 16 when compared to week 8 across all three zones in the control group (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). %<jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> in the control group was significantly greater across all three zones when compared to the test group at week 16 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Zone was found to be a significant main effect (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) that was independent of time and treatment with decreasing %<jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> in distant zones. %<jats:styled-content style=\"fixed-case\">RG<\/jats:styled-content> did not significantly change with time for both groups. There was a significant reduction in %<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content> in week 16 when compared to week 8 across all three zones in the control group (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). %<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content> in the test group was significantly greater across all zones when compared to the control group at week 16 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both groups exhibited very similar histomorphometric measurements in the zones proximal to the resident sinus wall. The % <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content> and % <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> were greatest in the zones proximal to resident bony walls and gradually decreased as the distance from the proximal walls increased. There was greater % <jats:styled-content style=\"fixed-case\">NB<\/jats:styled-content> and % <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> in the control group when compared to the test group in the distant zone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12652","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T06:16:15Z","timestamp":1435990575000},"page":"734-743","source":"Crossref","is-referenced-by-count":23,"title":["A histomorphometric assessment of collagen\u2010stabilized anorganic bovine bone mineral in maxillary sinus augmentation \u2013 a randomized controlled trial in sheep"],"prefix":"10.1111","volume":"27","author":[{"given":"Jamil","family":"Alayan","sequence":"first","affiliation":[{"name":"School of Dentistry and Oral Health Centre for Medicine and Oral Health Griffith University Southport Qld 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