{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:01:40Z","timestamp":1769090500941,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the 3\u2010year clinical and radiographic data of fixed implant\u2010supported dental prosthesis delivered to patients having taken alendronate 35\u201370\u00a0mg weekly for at least 3\u00a0years before implant placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Forty consecutive patients treated with oral bisphosphonates and requiring an implant\u2010supported restoration were recruited in two private centers between January 2008 and December 2011. Implants were inserted through minimally invasive approach under antibacterial and antibiotic treatment, 6\u00a0months after alendronate administration stopping. After 4\u00a0months of submerged healing, implants underwent prosthetic loading. Hygiene maintenance and clinical assessments were scheduled every 4\u00a0months for 3\u00a0years. Outcome measures were the following: implant and prosthetic success, survival rates, any observed clinical complications, marginal bone remodeling, probing pocket depth and bleeding\u2010on\u2010probing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of the study, eight patients dropped out. The final sample size resulted in 32 consecutive partially or fully edentulous patients (32 females; mean age 64.6\u00a0years) with 98 submerged implants. In only one patient, maxillary implant failed during healing period. No prosthesis failed during the entire follow\u2010up, and no major complications were recorded. Implant and prostheses success resulted in an overall survival rate of 98, 98% and 100%, respectively. Three\u2010year mean marginal bone loss was 1.35\u00a0\u00b1\u00a00.21 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95% 1.24\u20131.38). Successful soft tissue parameters were found around all implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral bisphosphonate therapy did not appear to significantly affect implant survival and success in case of accurate treatment time selection, minimally invasive surgical approach and constant follow\u2010up. Further prospective studies involving larger sample sizes and longer durations of follow\u2010up are required to confirm these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12662","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T16:35:49Z","timestamp":1436891749000},"page":"943-949","source":"Crossref","is-referenced-by-count":30,"title":["Dental implants treatment outcomes in patient under active therapy with alendronate: 3\u2010year follow\u2010up results of a multicenter prospective observational study"],"prefix":"10.1111","volume":"27","author":[{"given":"Marco","family":"Tallarico","sequence":"first","affiliation":[{"name":"Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Canullo","sequence":"additional","affiliation":[{"name":"Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erta","family":"Xhanari","sequence":"additional","affiliation":[{"name":"Tirana Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio Mario","family":"Meloni","sequence":"additional","affiliation":[{"name":"Dentistry Unit University Hospital of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512472335"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.te41"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12526"},{"key":"e_1_2_8_5_1","first-page":"201","article-title":"Screening, diagnosis and treatment of osteoporosis: a brief review","volume":"11","author":"Bernabei R.","year":"2014","journal-title":"Clinical Cases in Mineral and Bone Metabolism"},{"key":"e_1_2_8_6_1","volume-title":"Tissue\u2010Integrated Prostheses: Osseointegration in Clinical Dentistry","author":"Br\u00e5nemark P.I.","year":"1985"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1990.010105.x"},{"key":"e_1_2_8_8_1","volume-title":"Quality Evaluation for Dental Care: Guidelines for the Assessment of Clinical Quality and Professional Performance and the Standards for the Program Design to Assure the Quality of Care","author":"California Dental Association","year":"1976"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/212901a0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.09.019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2012.04.002"},{"key":"e_1_2_8_12_1","first-page":"349","article-title":"Safety of oral bisphosphonates: controlled studies on alveolar bone","volume":"21","author":"Jeffcoat M.K.","year":"2006","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04524"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.11.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0905480"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2685"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.04.054"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2009.06.005"},{"key":"e_1_2_8_19_1","first-page":"159","article-title":"Survival of dental implants in bisphosphonate users versus non\u2010users: a systematic review","volume":"20","author":"Kumar M.N.","year":"2012","journal-title":"The European Journal of Prosthodontics and Restorative Dentistry"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12088"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01772.x"},{"key":"e_1_2_8_22_1","first-page":"1216","article-title":"Oral bisphosphonates: early endosseous dental implant success and crestal bone changes. A retrospective study","volume":"27","author":"Memon S.","year":"2012","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_8_23_1","first-page":"711","article-title":"Nitrogen\u2010containing bisphosphonate mechanism of action","volume":"4","author":"Reszka A.A.","year":"2004","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4477.2009.00213.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.08.016"},{"key":"e_1_2_8_26_1","first-page":"146","article-title":"Osteonecrosis in the jaws of patients who are using oral biphosphonates to treat osteoporosis","volume":"22","author":"Russo Dello N.M.","year":"2007","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_8_27_1","first-page":"429","article-title":"Clinical guidelines for prevention of osteonecrosis of the jaws in patients in treatment with bisphosphonates: literature review and report of three cases","volume":"57","author":"Sarzi Amad\u00e8 D.","year":"2008","journal-title":"Minerva Stomatologica"},{"key":"e_1_2_8_28_1","first-page":"13","article-title":"Clinical and radiological outcomes of 1\u2010 versus 2\u2010stage implant placement: 1\u2010year results of a randomised clinical trial","volume":"4","author":"Tallarico M.","year":"2011","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02189.x"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.12662","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.12662","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.12662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:43:56Z","timestamp":1695476636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.12662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/clr.12662"],"URL":"https:\/\/doi.org\/10.1111\/clr.12662","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]}}}