{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:37:17Z","timestamp":1788183437687,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Salivary biomarkers may enhance diagnostic sensitivity for peri\u2010implant disease assessment. This study aimed to investigate the association of salivary periodontopathogen count and salivary interleukin\u20101beta (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2) level with the peri\u2010implant crevicular fluid <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 response at peri\u2010implant mucositis (<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>) sites among subjects with differing periodontal disease susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Eighty\u2010seven partially edentulous subjects having at least one implant with peri\u2010implant mucositis were included: 40 with history of chronic periodontitis (P) and 47 with no history of periodontitis (NP). Salivary <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2, peri\u2010implant crevicular fluid (<jats:styled-content style=\"fixed-case\">PICF<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2, and salivary red complex pathogen counts were recorded. Subjects were scored according to a threshold salivary pathogen level of more than 5log (10) counts and assigned a \u201cred complex score.\u201d Quartiles of salivary and <jats:styled-content style=\"fixed-case\">PICF IL<\/jats:styled-content>\u20101\u03b2 levels were also scored. Area under receiver operating curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) was computed to predict the highest <jats:styled-content style=\"fixed-case\">PICF IL<\/jats:styled-content>\u20101\u03b2 score using salivary biomarker as predictors and age\u2010adjusted logistic regression performed for the significant predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> group, red complex score (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\u00a0=\u00a00.758 <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010) (odds ratio\u00a0=\u00a01.377) and salivary <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\u00a0=\u00a00.708 <jats:italic>P<\/jats:italic>\u00a0=\u00a00.038) (odds ratio\u00a0=\u00a02.506) were significant predictors of highest <jats:styled-content style=\"fixed-case\">PICF IL<\/jats:styled-content>\u20101\u03b2 quartile score. In the P group, no significant associations were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Salivary biomarkers could distinguish the \u201chigh\u201d pro\u2010inflammatory responders at <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> sites only in subjects without inherent periodontal disease susceptibility. Periodontal susceptibility may impact the immuno\u2010inflammatory response in sub\u2010peri\u2010implant niches of those with peri\u2010implant mucositis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12713","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T22:50:37Z","timestamp":1444690237000},"page":"662-667","source":"Crossref","is-referenced-by-count":19,"title":["Salivary IL\u20101\u03b2 and red complex bacteria as predictors of the inflammatory status in sub\u2010peri\u2010implant niches of subjects with peri\u2010implant mucositis"],"prefix":"10.1111","volume":"27","author":[{"given":"Aneesha","family":"Acharya","sequence":"first","affiliation":[{"name":"Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"},{"name":"Dr D Y Patil Dental College and Hospital Pimpri Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Leng","family":"Koh","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Kheur","sequence":"additional","affiliation":[{"name":"Dr D Y Patil Dental College and Hospital Pimpri Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory. 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