{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:04:11Z","timestamp":1790442251873,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T00:00:00Z","timestamp":1447459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DENTSPLY Implants, Mannheim, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The overall aim of the study was to investigate a biofunctionalized implant surface with electrochemically deposition of hydroxyapatite and the synthetic peptide (P\u201015) and its effect on osseointegration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Three modified implant types of <jats:styled-content style=\"fixed-case\">ANKYLOS<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> C\/X implants were used; (1) machined implants used as negative control (M, <jats:italic>n<\/jats:italic>\u00a0=\u00a020), (2) implants with the <jats:styled-content style=\"fixed-case\">FRIADENT<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> plus surface (grit blasted and acid\u2010etched) used as positive control (P, <jats:italic>n<\/jats:italic>\u00a0=\u00a020), and (3) implants with a biomimetic surface consisting of hydroxyapatite and the synthetic 15 aminoacids containing peptide P\u201015 (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a040). The implants were randomly inserted in the mandibles of 10 beagle dogs following 4\u00a0months after tooth extraction (P1\u2010P4). Three animals were sacrificed 2 and 7\u00a0days after implant insertion, respectively, and four animals were sacrificed 6\u00a0months post implant insertion. Bone\u2010to\u2010implant contacts (<jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content>s) were analyzed via histomorphometrical analyses at five different region of interests (<jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>s); two at the middle part on either side of the implant (<jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content> 1\/4), two at the apical part of the implant at each side (<jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content> 2\/3), and one at the tip of the implant (<jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content> 5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All implant surfaces showed a high level of osseointegration and osteoconductivity. The cumulative implant survival rate (<jats:styled-content style=\"fixed-case\">CSR<\/jats:styled-content>) was 93.8%, 100% in the M, 85% in the P, and 95% in the <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> group. No statistical difference in <jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content>s at <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content> 1\/4, 2\/3, and 5 could be shown between implant types following 2 and 7\u00a0days of healing. <jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content> values increased in all groups over time. After 6\u00a0months of healing the <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> group showed superiority in <jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content> 2\/3 (73.2\u00a0\u00b1\u00a015.6%) compared to the P (48.3\u00a0\u00b1\u00a010.6%) and M group (66.3\u00a0\u00b1\u00a030.2%) with a significant difference between <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and P (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is hypothesized, that the surface biofunctionalization improves peri\u2010implant bone formation and remodeling, leading to an increased bone\u2010to implant contact. However, within the limitations of the study set\u2010up no benefit in the early phase of osseointegration could be established for dental implants with P\u201015 containing surface in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12723","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T07:35:00Z","timestamp":1447486500000},"page":"1339-1348","source":"Crossref","is-referenced-by-count":18,"title":["In vivo evaluation of biofunctionalized implant surfaces with a synthetic peptide (P\u201015) and its impact on osseointegration. 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