{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:30:11Z","timestamp":1787499011284,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["228415"],"award-info":[{"award-number":["228415"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The primary objective was to assess osseointegration of implants with dehiscence defects grafted with a TiO\n                      <jats:sub>2<\/jats:sub>\n                      scaffold. The secondary objective was to assess the performance of the scaffold in terms of mechanical stability and bone fill.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      Five minipigs had the mandibular premolars extracted. After healing, two dental implants (\n                      <jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content>\n                      ctive\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , Institut Straumann\n                      <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>\n                      , Basel, Switzerland) with associated semi\u2010cylindrical dehiscence defects (\u00d8\u00a0=\u00a06\u00a0mm, height\u00a0=\u00a010\u00a0mm) were installed in each quadrant. The defects were grafted with test scaffolds (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010) or control autologous bone blocks (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010). After 3\u00a0months submerged healing, the pigs were euthanized and the sites analysed by microcomputed tomography and histology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four minipigs were available for second stage surgery; (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a09) experimental and (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07) control sites. The mean bone\u2010to\u2010implant contact on the defect side was 82% (\u00b110%) and 79% (\u00b111%) in the test and control groups respectively. The mean level of first bone\u2010to\u2010implant contact was more coronal on the defect side in the test group 3.2\u00a0mm (\u00b10.4\u00a0mm) than in the control group 3.6\u00a0mm (\u00b11.1\u00a0mm). The defect area occupied by bone within the extent of the scaffold varied, but averaged 37% (\u00b114.6%) whereas the material itself occupied 7.4% (\u00b13.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the limitations of the study, the results suggest that the novel synthetic scaffold material perform similar to the autologous bone block control with respect to implant osseointegration. The mechanical properties of the scaffold appeared sufficient to withstand clinical load in the present experimental model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.12725","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T06:52:27Z","timestamp":1448002347000},"page":"1200-1206","source":"Crossref","is-referenced-by-count":13,"title":["TiO\n                    <sub>2<\/sub>\n                    scaffolds in peri\u2010implant dehiscence defects: an experimental pilot study"],"prefix":"10.1111","volume":"27","author":[{"given":"Anders","family":"Verket","sequence":"first","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Dentistry, University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Dentistry, University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan Caspar","family":"Wohlfahrt","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Clinical Dentistry, University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e5le Petter","family":"Lyngstadaas","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Dentistry, University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Eirik","family":"Ellingsen","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Institute of Clinical Dentistry, University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5vard","family":"Jostein Haugen","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Dentistry, University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-7233","authenticated-orcid":false,"given":"Hanna","family":"Tiainen","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Dentistry, University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1999.100104.x"},{"key":"e_1_2_6_3_1","first-page":"143","article-title":"Variations in bone regeneration adjacent to implants augmented with barrier membranes alone or with demineralized freeze\u2010dried bone or autologous grafts: a study in dogs","volume":"10","author":"Becker W.","year":"1995","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.12.034"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.140201.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01781.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.090607.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01565.x"},{"key":"e_1_2_6_9_1","first-page":"95","article-title":"Injectable magnesium\u2010enriched hydroxyapatite putty in peri\u2010implant defects: a histomorphometric analysis in pigs","volume":"27","author":"Crespi R.","year":"2012","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2011.10.032"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2014.6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-81"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1982.tb00172.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003607.pub3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jeurceramsoc.2009.03.017"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01821.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.07.007"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.11.022"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1998.090302.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.5.648"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.09.009"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.11.017"},{"key":"e_1_2_6_23_1","first-page":"588","article-title":"Clinical evaluation of alveolar ridge preservation with a \u00df\u2010tricalcium phosphate socket graft","volume":"30","author":"Horowitz R.A.","year":"2009","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_6_24_1","first-page":"218","article-title":"Bone augmentation procedures in localized defects in the alveolar ridge: clinical results with different bone grafts and bone\u2010substitute materials","volume":"24","author":"Jensen S.S.","year":"2009","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2007.06.002"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2013.07.026"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.04.044"},{"issue":"304","key":"e_1_2_6_28_1","first-page":"e1","article-title":"Guided bone regeneration using chitosan\u2010collagen membranes in dog dehiscence\u2010type defect model","volume":"72","author":"Li X.","year":"2014","journal-title":"Journal of Oral and Maxillofacial Surgery"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12354"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01939.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01408.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01868.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080061"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90218-F"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328209354925"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515594780"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.05.017"},{"key":"e_1_2_6_38_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1600-051X.2007.01159.x","article-title":"Bone regeneration in dehiscence\u2010type defects at non\u2010submerged and submerged chemically modified (SLActive\u00ae) and conventional SLA titanium implants: an immunohistochemical study in dogs","volume":"35","author":"Schwarz F.","year":"2008","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51244"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12109"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-010-4142-1"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jeurceramsoc.2012.08.016"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.02.020"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2011.00408.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00832.x"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.12725","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.12725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T11:44:29Z","timestamp":1718192669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.12725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,20]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/clr.12725"],"URL":"https:\/\/doi.org\/10.1111\/clr.12725","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,20]]}}}