{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:37:24Z","timestamp":1792179444935,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Michigan Periodontal Graduate Student Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To study the effect of the recombinant human bone morphogenetic protein 2 (rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102) on sinus volumetric and histometric changes after sinus floor augmentation compared to a conventional approach of non\u2010biologic bone grafting materials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>An electronic search of 4 databases (January 1990\u2013February 2015), including PubMed\/<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>, Web of Science and Cochrane Central, and a hand search of peer\u2010reviewed journals for relevant articles were performed. Human clinical trials with data on comparison of sinus volumetric and\/or histometric outcomes with and without the use of rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 in sinus grafting procedures, with \u226510 augmentation sites in each study group, and with a follow\u2010up period of at least 6\u00a0months, were included. Random\u2010effects meta\u2010analyses were performed to analyze weighted mean difference (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>) and confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) for the recorded variables according to <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content> guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) were included. The results of the meta\u2010analyses showed that the <jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> of vertical bone height gain was \u22120.14\u00a0mm (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a0\u22121.91 to 1.62\u00a0mm, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.87), the <jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> of bone density was \u2212142.42\u00a0mg\/cm<jats:sup>3<\/jats:sup> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a0\u2212310.62\u201325.78\u00a0mg\/cm<jats:sup>3<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.10), the <jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> of the percentage of vital bone was \u22124.59% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a0\u221211.73\u20132.56%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.21), and the <jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> of the percentage of residual bone grafting materials was \u22129.90% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a0\u221226.38\u20136.58%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.21). The comparison of implant survival rate presented an overall risk ratio of 1.00 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.94\u20131.07). The two approaches (conventional bone grafting compared to <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>s) demonstrated comparable effectiveness for both clinical and histomorphometric measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This systematic review revealed that the use of rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 in maxillary sinus floor augmentation achieved similar clinical and histometric outcomes when compared to conventional sinus grafting procedures after a healing period of 6\u20139\u00a0months. However, previous studies showed the morbidity and other patient\u2010reported outcomes were improved in rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 approaches as compared to bone autograft procedures (both intraoral and extraoral bone harvesting because no donor site is required). Long\u2010term studies are required to determine the cost\u2010benefit of sinus floor augmentation procedures for patients requiring implant reconstruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12737","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T07:34:48Z","timestamp":1448955288000},"page":"1349-1359","source":"Crossref","is-referenced-by-count":32,"title":["Recombinant human bone morphogenetic protein 2 outcomes for maxillary sinus floor augmentation: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"Guo\u2010Hao","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Periodontics Department of Periodontics &amp; Oral Medicine University of Michigan School of Dentistry Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glendale","family":"Lim","sequence":"additional","affiliation":[{"name":"Graduate Periodontics Department of Periodontics &amp; Oral Medicine University of Michigan School of Dentistry Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsun\u2010Liang","family":"Chan","sequence":"additional","affiliation":[{"name":"Graduate Periodontics Department of Periodontics &amp; Oral Medicine University of Michigan School of Dentistry Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William V.","family":"Giannobile","sequence":"additional","affiliation":[{"name":"Graduate Periodontics Department of Periodontics &amp; Oral Medicine University of Michigan School of Dentistry Ann Arbor MI USA"},{"name":"Department of Biomedical Engineering College of Engineering University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Periodontics Department of Periodontics &amp; Oral Medicine University of Michigan School of Dentistry Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200208151-00017"},{"key":"e_1_2_8_3_1","first-page":"416","article-title":"Bone density assessments of dental implant sites: 2. 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