{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T09:49:36Z","timestamp":1723283376818},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ARDEC, Ariminum Odontologica SRL, Rimini, Italy"},{"name":"Clinical Research Foundation (CRF)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the healing outcomes at buccal dehiscence defects after 4\u00a0months following implant placement immediately into extraction sockets (<jats:styled-content style=\"fixed-case\">IPIES<\/jats:styled-content>) and filled with a mixture of synthetic hydroxyl apatite (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>) 60% and \u03b2\u2010tri\u2010calcium phosphate (\u03b2\u2010<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content>) 40% in comparison with leaving a blood clot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Eight Labrador dogs were used, and an implant was placed immediately following tooth extraction into the distal alveolus of the third premolars, bilaterally. Standardized buccal defects, 8\u00a0mm in depth and 4\u00a0mm in width at the coronal and 2\u00a0mm in width at the apical outlines were created. A mixture of synthetic <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> 60% and \u03b2\u2010<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content> 40% was used to fill the defects at the test sites, while the control sites were left unfilled. Collagen membranes were used to cover the defects at both sides, and a non\u2010submerged healing was allowed. After 4\u00a0months of healing, biopsies were obtained and processed for morphometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A vertical gain in the extent of the bony crest and of osseointegration levels of 4.2\u00a0\u00b1\u00a02.4 and 3.3\u00a0\u00b1\u00a02.1\u00a0mm at the test sites and of 5.0\u00a0\u00b1\u00a00.8 and 4.6\u00a0\u00b1\u00a01.0\u00a0mm at the control sites, respectively, were observed. <jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content>% within the buccal defects reached similar levels (37\u201342%) both at test and control sites. None of the means of the variables differed significantly between the two groups. New bone formation within the defects was higher, and the percentage of the connective tissue was lower at the control (65.7\u00a0\u00b1\u00a011.7% and 2.5\u00a0\u00b1\u00a03.3%, respectively) compared to the test sites (16.8\u00a0\u00b1\u00a011.3% and 48.9\u00a0\u00b1\u00a029.5%, respectively). These differences were statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of a mixture of synthetic <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> 60% and \u03b2\u2010<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content> 40% to fill surgically created buccal dehiscence defects at <jats:styled-content style=\"fixed-case\">IPIES<\/jats:styled-content> sites covered with a collagen membrane did not improve osseointegration in the defect area.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12765","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T06:53:18Z","timestamp":1451890398000},"page":"1462-1468","source":"Crossref","is-referenced-by-count":6,"title":["Healing of BoneCeramic<sup>\u2122<\/sup> at buccal dehiscence defects at implants installed immediately into extraction sockets. An experimental study in dogs"],"prefix":"10.1111","volume":"27","author":[{"given":"Enzo","family":"De Santis","sequence":"first","affiliation":[{"name":"ARDEC Ariminum Odontologica Rimini Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklaus P.","family":"Lang","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine University of Zurich Zurich Switzerland"},{"name":"University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz A.","family":"Salata","sequence":"additional","affiliation":[{"name":"USP Faculty of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via P.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry of Ara\u00e7atuba UNESP \u2013 Univ Estadual Paulista S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Favero","sequence":"additional","affiliation":[{"name":"Private Practice Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[{"name":"ARDEC Ariminum Odontologica Rimini Italy"},{"name":"Faculty of Dentistry of Ara\u00e7atuba UNESP \u2013 Univ Estadual Paulista S\u00e3o Paulo Brazil"},{"name":"POI\u2010Programa Odontol\u00f3gico Internacional Cartagena de Indias 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