{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T04:15:03Z","timestamp":1777176903938,"version":"3.51.4"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T00:00:00Z","timestamp":1452124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DENTSPLY Implants, M\u00f6lndal, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Osteoporosis has been called a potential risk factor for bone healing around implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this multicentre study was to verify the clinical performance of fluoridated implants in the maxilla of subjects with diagnosed systemic primary osteoporosis\/osteopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Postmenopausal women in need of 2\u20138 splinted implants in maxilla underwent bone mineral density measurements in the hip and spine, using dual\u2010energy X\u2010ray absorptiometry scans. Based on their T\u2010scores, they were divided into two study groups: Group O (osteoporosis\/osteopenia group) subjects had a T\u2010score \u2264\u22122, Group C (control group) had a T\u2010score of \u2265\u22121, and subjects with a T\u2010score &lt;\u22121 but &gt;\u22122 were excluded. Implants were placed with a two\u2010stage procedure and loaded 4\u20138\u00a0weeks after abutment surgery. At 6\u00a0months and 1\u00a0year after functional loading, clinical parameters (including peri\u2010apical radiographs) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and forty\u2010eight implants were placed in 48 subjects (mean age: 67\u00a0years (range [59\u201383]). Sixty\u2010three implants were placed in 20 osteoporosis subjects (Group O, mean age: 69\u00a0years; range [59\u201383]), and 85 were placed in control subjects (Group C, mean age: 65\u00a0years; range [60\u201374]). The cumulative survival rate, on an implant level, was 99.3% (Group O: 98.4%; Group C: 100.0%). The cumulative survival rate, on a subject level, was 97.9% (Group O: 94.7%; Group C: 100.0%). Marginal bone level (<jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>) alterations from functional loading to the 1\u2010year follow\u2010up visit were measured on an implant level and a subject level. The overall <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> alteration on an implant level was \u22120.01\u00a0\u00b1\u00a00.51\u00a0mm (Group O: \u22120.11\u00a0\u00b1\u00a00.49\u00a0mm; Group C: 0.05\u00a0\u00b1\u00a00.52\u00a0mm). The overall <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> alteration on a subject level was \u22120.04\u00a0\u00b1\u00a00.27\u00a0mm (Group O: \u22120.17\u00a0\u00b1\u00a00.30\u00a0mm; Group C: 0.04\u00a0\u00b1\u00a00.23\u00a0mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of this prospective, non\u2010randomized, controlled, multicentre study, it can be concluded that oral implant therapy in patients suffering from osteoporosis\/osteopenia is a reliable treatment option with comparable integration rates as in healthy patients. Long\u2010term follow of the study groups is necessary to compare marginal bone alterations and treatment outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12766","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T07:39:10Z","timestamp":1452238750000},"page":"95-102","source":"Crossref","is-referenced-by-count":39,"title":["An open, prospective, non\u2010randomized, controlled, multicentre study to evaluate the clinical outcome of implant treatment in women over 60\u00a0years of age with osteoporosis\/osteopenia: 1\u2010year results"],"prefix":"10.1111","volume":"28","author":[{"given":"Andy","family":"Temmerman","sequence":"first","affiliation":[{"name":"Section of Periodontology Department of Oral Health Sciences KU Leuven &amp; Dentistry University Hospitals KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Rasmusson","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"K\u00fcbler","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Plastic Surgery University of Wuerzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Thor","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Institute of Surgical Sciences Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Quirynen","sequence":"additional","affiliation":[{"name":"Section of Periodontology Department of Oral Health Sciences KU Leuven &amp; Dentistry University Hospitals KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,7]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"347","article-title":"Long\u2010term follow\u2010up study of osseointegrated implants in the treatment of totally edentulous jaws","volume":"5","author":"Adell R.","year":"1990","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(81)80077-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-09-00092"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0295-7"},{"key":"e_1_2_8_6_1","first-page":"416","article-title":"Bone density assessments of dental implant sites: 2. 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