{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:50:46Z","timestamp":1789372246619,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["24593127"],"award-info":[{"award-number":["24593127"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>There are a few experimental models that clearly describe the pathological differences in tissue destruction between periodontitis and peri\u2010implantitis. We recently reported that the formation of immune complexes accelerates site\u2010specific loss of attachment and alveolar bone resorption when an antigen is topically applied in the gingival sulcus of an immunized rat. We applied this model to the peri\u2010implant tissues and compared peri\u2010implant destruction to periodontitis without using a ligature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Twenty\u2010five rats were used in this study and were divided into five groups. Implantation was performed immediately after extraction of right first molars in rats. The left first molars were left untreated to be examined as natural teeth. The immunized group consisted of rats that had received intraperitoneal lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>), whereas the nonimmunized group received only phosphate\u2010buffered saline (<jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content>). The untreated baseline group received only implantation. After intraperitoneal booster injection, half of each group received topical application of <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> in the palatal gingival sulcus daily for 3\u00a0days. The other half of the groups received <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content>. Histopathological and histometrical findings were observed with hematoxylin and eosin staining, collagen fibers were observed with Azan staining, and formation of immune complexes was immunohistologically evaluated by C1qB expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Peri\u2010implant tissue destruction was greater in the immunized and <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010applied groups than in the other groups. No periodontal destruction was observed. Formation of immune complexes was observed in the junctional epithelium and adjacent connective tissue in the immunized groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antigen\u2010induced peri\u2010implant tissue destruction occurs faster than periodontal tissue destruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12777","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T07:33:15Z","timestamp":1453707195000},"page":"163-170","source":"Crossref","is-referenced-by-count":46,"title":["Histopathological comparison of the onset of peri\u2010implantitis and periodontitis in rats"],"prefix":"10.1111","volume":"28","author":[{"given":"Yuzo","family":"Takamori","sequence":"first","affiliation":[{"name":"Unit of Translational Medicine, Course of Medicine, and Dental Sciences Department of Periodontology Nagasaki University Graduate School of Biomedical Science Nagasaki 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