{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:16:41Z","timestamp":1791821801968,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CAMLOG Foundation","award":["CF40806"],"award-info":[{"award-number":["CF40806"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of the present randomized controlled clinical study was to test whether small bony dehiscence defects (\u22645\u00a0mm) left to heal spontaneously result in the same clinical and radiological outcome as defects treated with guided bone regeneration (GBR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010two patients who received at least one implant with a small bony dehiscence defect were enrolled in the study. If the defect height was \u22645\u00a0mm, the site was randomly assigned to either the spontaneous healing (SH) group or the GBR group. In the SH group, the defect was left without any treatment. In the GBR group, the defects around the implants were grafted with deproteinized bovine bone mineral (DBBM) and covered with a native collagen membrane. Clinical and radiographic measurements were performed 6\u00a0months after implant placement with a reentry surgery and at the time of crown insertion and the subsequent follow\u2010up appointments at 3, 6, 12 and 18\u00a0months after loading. For statistical analyses, the mixed linear model was applied for the clinical and radiographic measurements observed around the implants. Simple comparisons of the location of the measurements in the two independent groups are performed with the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010test. In addition, the mixed model assumptions were checked.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The implant and crown survival rate 18\u00a0months after loading was 100%, revealing no serious biologic or prosthetic complication. The mean changes of the buccal vertical bone height between implant placement and reentry surgery after 6\u00a0months revealed a small bone loss of \u22120.17\u00a0\u00b1\u00a01.79\u00a0mm (minimum \u22124\u00a0mm and maximum 2.5\u00a0mm) for the SH group and a bone gain of 1.79\u00a0\u00b1\u00a02.24\u00a0mm (minimum of \u22122.5\u00a0mm and maximum of 5\u00a0mm) for the GBR group, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.017). Radiographic measurements demonstrated a slight bone loss of \u22120.39\u00a0\u00b1\u00a00.49\u00a0mm for the SH group and a stable bone level of 0.02\u00a0\u00b1\u00a00.48\u00a0mm for GBR group after 18\u00a0months. All peri\u2010implant soft tissue parameters revealed healthy tissues with no difference between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Small bony dehiscence defects left for spontaneous healing demonstrated high implant survival rates with healthy and stable soft tissues. However, they revealed more vertical bone loss at the buccal aspect 6\u00a0months after implant insertion and also more marginal bone loss between crown insertion and 18\u00a0months after loading compared to sites treated with GBR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.12806","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T03:04:08Z","timestamp":1456715048000},"page":"348-354","source":"Crossref","is-referenced-by-count":97,"title":["A randomized controlled clinical trial comparing small buccal dehiscence defects around dental implants treated with guided bone regeneration or left for spontaneous healing"],"prefix":"10.1111","volume":"28","author":[{"given":"Ronald E.","family":"Jung","sequence":"first","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Herzog","sequence":"additional","affiliation":[{"name":"Private Practice Affoltern a.A. Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Wolleb","sequence":"additional","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Ramel","sequence":"additional","affiliation":[{"name":"Private Practice Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph H. F.","family":"H\u00e4mmerle","sequence":"additional","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02253.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1997.080206.x"},{"key":"e_1_2_7_4_1","first-page":"405","article-title":"Tissue integration of one\u2010stage iti implants: 3\u2010year results of a longitudinal study with hollow\u2010cylinder and hollow\u2010screw implants","volume":"6","author":"Buser D.","year":"1991","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.261001.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1998.tb00132.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012001009.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01634.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02547.x"},{"key":"e_1_2_7_10_1","first-page":"107","article-title":"Gingival sulcus bleeding \u2013 a leading symptom in initial gingivitis","volume":"15","author":"Muhlemann H.R.","year":"1971","journal-title":"Helvetica Odontologica Acta"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1994.050206.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1994.050409.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1997.080410.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_7_15_1","first-page":"159","article-title":"Treatment of dehiscences and fenestrations around dental implants using resorbable and nonresorbable membranes associated with bone autografts: a comparative clinical study","volume":"12","author":"Simion M.","year":"1997","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030405.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028006517.x"},{"key":"e_1_2_7_18_1","first-page":"844","article-title":"Resorbable versus nonresorbable membranes in combination with bio\u2010oss for guided bone regeneration","volume":"12","author":"Zitzmann N.U.","year":"1997","journal-title":"International Journal of Oral and Maxillofacial Implants"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.12806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.12806","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.12806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:37:54Z","timestamp":1696286274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.12806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,29]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/clr.12806"],"URL":"https:\/\/doi.org\/10.1111\/clr.12806","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,29]]}}}