{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:22:58Z","timestamp":1781648578935,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T00:00:00Z","timestamp":1457568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ARDEC Academy"},{"name":"Ariminum Odontologica s.r.l., Rimini"},{"name":"Clinical Research Foundation (CRF) for the Promotion of Oral Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the healing at elevated sinus floors augmented either with deproteinized bovine bone mineral (<jats:styled-content style=\"fixed-case\">DBBM<\/jats:styled-content>) or autologous bone grafts and followed by immediate implant installation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Twelve albino New Zealand rabbits were used. Incisions were performed along the midline of the nasal dorsum. The nasal bone was exposed. A circular bony widow with a diameter of 3\u00a0mm was prepared bilaterally, and the sinus mucosa was detached. Autologous bone (<jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>) grafts were collected from the tibia. Similar amounts of <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">DBBM<\/jats:styled-content> granules were placed below the sinus mucosa. An implant with a moderately rough surface was installed into the elevated sinus bilaterally. The animals were sacrificed after 7 (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) or 40\u00a0days (<jats:italic>n<\/jats:italic>\u00a0=\u00a06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The dimensions of the elevated sinus space at the <jats:styled-content style=\"fixed-case\">DBBM<\/jats:styled-content> sites were maintained, while at the <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content> sites, a loss of 2\/3 was observed between 7 and 40\u00a0days of healing. The implants showed similar degrees of osseointegration after 7 (7.1\u00a0\u00b1\u00a01.7%; 9.9\u00a0\u00b1\u00a04.5%) and 40\u00a0days (37.8\u00a0\u00b1\u00a015%; 36.0\u00a0\u00b1\u00a011.4%) at the <jats:styled-content style=\"fixed-case\">DBBM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content> sites, respectively. Similar amounts of newly formed mineralized bone were found in the elevated space after 7\u00a0days at the <jats:styled-content style=\"fixed-case\">DBBM<\/jats:styled-content> (7.8\u00a0\u00b1\u00a06.6%) and <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content> (7.2\u00a0\u00b1\u00a06.0%) sites while, after 40\u00a0days, a higher percentage of bone was found at <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content> (56.7\u00a0\u00b1\u00a08.8%) compared to <jats:styled-content style=\"fixed-case\">DBBM<\/jats:styled-content> (40.3\u00a0\u00b1\u00a07.5%) sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> granules and autologous bone grafts contributed to the healing at implants installed immediately in elevated sinus sites in rabbits. Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> maintained the dimensions, while autologous bone sites lost 2\/3 of the volume between the two periods of observation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12825","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T07:13:08Z","timestamp":1457766788000},"page":"503-511","source":"Crossref","is-referenced-by-count":40,"title":["Healing at implants installed concurrently to maxillary sinus floor elevation with Bio\u2010Oss<sup>\u00ae<\/sup> or autologous bone grafts. A histo\u2010morphometric study in rabbits"],"prefix":"10.1111","volume":"28","author":[{"given":"Enzo","family":"De Santis","sequence":"first","affiliation":[{"name":"ARDEC Ariminum Odontologica Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklaus P.","family":"Lang","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine University of Zurich Zurich Switzerland"},{"name":"University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia UNESP \u2010 Universidade Estadual Paulista Ara\u00e7atuba (SP) Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idelmo","family":"Rangel Garcia Jr","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia UNESP \u2010 Universidade Estadual Paulista Ara\u00e7atuba (SP) Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Caneva","sequence":"additional","affiliation":[{"name":"ARDEC Ariminum Odontologica Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[{"name":"ARDEC Ariminum Odontologica Rimini Italy"},{"name":"Faculdade de Odontologia UNESP \u2010 Universidade Estadual Paulista Ara\u00e7atuba (SP) Brazil"},{"name":"POI\u2010Programa Odontol\u00f3gico Internacional Cartagena de Indias Bolivar Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"351","article-title":"Evaluation of titanium implants placed into simulated extraction sockets: a study in dogs","volume":"14","author":"Akimoto K.","year":"1999","journal-title":"International Journal of Oral Maxillofacial Implants"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130409.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00693.x"},{"key":"e_1_2_6_5_1","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and bone","volume":"38","author":"Boyne P.J.","year":"1980","journal-title":"Journal of Oral Surgery"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12261"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00208.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2005.tb00049.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01220.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1997.080409.x"},{"key":"e_1_2_6_11_1","first-page":"337","article-title":"Porous hydroxyapatite for grafting the maxillary sinus: a comparative histomorphometric study in sheep","volume":"17","author":"Haas R.","year":"2002","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1998.090206.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02245.x"},{"key":"e_1_2_6_14_1","first-page":"199","article-title":"Histomorphometric analysis of natural bone mineral for maxillary sinus augmentation","volume":"19","author":"John H.D.","year":"2004","journal-title":"The International Journal of Oral Maxillofacial Implants"},{"key":"e_1_2_6_15_1","volume-title":"Sinus Floor Augmentation Surgery Using Autologous Bone Grafts from Various Donor Sites: a Meta\u2010Analysis of the Total Bone Volume","author":"Klijn R.J.","year":"2010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02069.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2004.tb00217.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02227.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01964.x"},{"key":"e_1_2_6_20_1","volume-title":"Effects of a collagen membrane positioned between augmentation material and the sinus mucosa in the elevation of the maxillary sinus floor","author":"Scala A.","year":"2016"},{"key":"e_1_2_6_21_1","first-page":"53","article-title":"Histologic findings in sinus augmentation with autogenous bone chips versus a bovine bone substitute","volume":"18","author":"Schlegel K.A.","year":"2003","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1973.tb04629.x"},{"key":"e_1_2_6_23_1","first-page":"151","article-title":"\u201cMaxillary sinus grafting for endosseous implants\u201d. 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