{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:42:23Z","timestamp":1696408943713},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:00:00Z","timestamp":1459382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["12\u2010059"],"award-info":[{"award-number":["12\u2010059"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The compromised capacity of bone healing in osteoporotic population renders a serious concern of patients and clinicians. This study aimed to investigate the influence of G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> on bone reconstruction using an osteoporotic animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Sixty skeletal mature female Spraque\u2013Dawley rats underwent bilateral ovariectomy (OVX) and were assigned into three groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). Three months after OVX, defects of 5\u00a0mm in cranial and 2\u00a0mm in femur were surgically created on all the animals. The defects were left unfilled, filled with gelatin sponge (GS), or filled with granulocyte\u2010colony stimulating factor (G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) infused GS. Specimens were retrieved for histomorphometric and micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> analyses at weeks 1, 4, 8, and 12 after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At early stage of week 1 to week 8, the histomorphometric and micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> analysis demonstrated more advanced bone formation in femur in the control group; by week 12, all groups achieved cortical closure. In cranial bone, more advanced bone formation was exhibited in G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\u2010treated group at both early and late stages, although this observation was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results indicated that in osteoporotic bone, G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> may advance bone healing in cranial bone where spontaneous bone formation was insufficient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12839","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T17:13:56Z","timestamp":1459617236000},"page":"586-593","source":"Crossref","is-referenced-by-count":1,"title":["The influence of locally applied granulocyte\u2010colony stimulating factor\u00a0on osteoporotic bone"],"prefix":"10.1111","volume":"28","author":[{"given":"Xi 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