{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:31:48Z","timestamp":1793845908139,"version":"4.6.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008233","name":"Shanghai Jiao Tong University School of Medicine","doi-asserted-by":"publisher","award":["14XJ10023"],"award-info":[{"award-number":["14XJ10023"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371190"],"award-info":[{"award-number":["81371190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this 2\u2010year randomized controlled clinical trial was to assess the differences in implant survival rates, soft tissue preservation, patient centered outcome and crestal bone changes applying the minimally invasive (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) flapless approach for single implant placement compared to flapped implant surgery (<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Subjects eligible for this study were randomly assigned into two groups: <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>. Items of evaluation were the following: implant installation position, soft tissue healing, post\u2010surgical pain, soft tissue outcome, marginal bone loss (<jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>), and implant survival rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty subjects (14 women and 26 men, 20 in <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> group and 20 in <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> group with a mean of 39\u00a0\u00b1\u00a013.2\u00a0years old) were included in the study. None of the implants demonstrated dehiscence or loss during the follow\u2010up. Subjects in <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> group showed significantly lower post\u2010surgical pain and significantly less wound healing index scores at 1\u2010week follow\u2010up. The width of keratinized mucosa decreased from a mean of 4.2\u00a0\u00b1\u00a01.6\u00a0mm pre\u2010surgically to 3.7\u00a0\u00b1\u00a01.1\u00a0mm at crown delivery but remained stable at 2\u2010year follow\u2010up in <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> group. At every appointment in the study, no statistical significant difference of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> was found between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>, single implants placed applying the <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> technique in selected subjects showed advantages in improving patient comfort and decreasing post\u2010implant placement soft tissue reaction. Meanwhile, implants with <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> approach have the same level of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> and high success rates as <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> procedure at 2\u2010year follow\u2010up. The deduction of keratinized mucosa is very limited and the width of <jats:styled-content style=\"fixed-case\">KM<\/jats:styled-content> remained stable with <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> approach at 2\u2010year follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12875","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T21:42:25Z","timestamp":1463866945000},"page":"757-764","source":"Crossref","is-referenced-by-count":29,"title":["Minimally invasive flapless vs. flapped approach for single implant placement: a 2\u2010year randomized controlled clinical trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Feng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oral Implantology Ninth People's Hospital School of Medicine Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Ninth People's Hospital School of Medicine Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Ninth People's Hospital School of Medicine Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology Ninth People's Hospital School of Medicine Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University Shanghai 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