{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:04:10Z","timestamp":1790442250378,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF\u20102014R1A1A1A05002953"],"award-info":[{"award-number":["NRF\u20102014R1A1A1A05002953"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the study was to test whether or not the use of a polyethylene glycol (PEG) hydrogel with or without the addition of an arginylglycylaspartic acid (RGD) sequence applied as a matrix in combination with hydroxyapatite\/tricalciumphosphate (HA\/TCP) results in similar peri\u2010implant bone regeneration as traditional guided bone regeneration procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      In 12 beagle dogs, implant placement and peri\u2010implant bone regeneration were performed 2\u00a0months after tooth extraction in the maxilla. Two standardized box\u2010shaped defects were bilaterally created, and dental implants were placed in the center of the defects with a dehiscence of 4\u00a0mm. Four treatment modalities were randomly applied:\n                      <jats:styled-content style=\"fixed-case\">i)HA<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content>\n                      mixed with a synthetic\n                      <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\n                      hydrogel,\n                      <jats:styled-content style=\"fixed-case\">ii)HA<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content>\n                      mixed with a synthetic\n                      <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\n                      hydrogel supplemented with an\n                      <jats:styled-content style=\"fixed-case\">RGD<\/jats:styled-content>\n                      sequence,\n                      <jats:styled-content style=\"fixed-case\">iii)HA<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content>\n                      covered with a native collagen membrane (\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      ), iv)and no bone augmentation (empty). After a healing period of 8 or 16\u00a0weeks, micro\u2010\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      and histological analyses were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Histomorphometric analysis revealed a greater relative augmented area for groups with bone augmentation (43.3%\u201353.9% at 8\u00a0weeks, 31.2%\u201342.8% at 16\u00a0weeks) compared to empty controls (22.9% at 8\u00a0weeks, 1.1% at 16\u00a0weeks). The median amount of newly formed bone was greatest in group\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      at both time\u2010points. Regarding the first bone\u2010to\u2010implant contact,\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      was statistically significantly superior to all other groups at 8\u00a0weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Bone can partially be regenerated at peri\u2010implant buccal dehiscence defects using traditional guided bone regeneration techniques. The use of a\n                      <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\n                      hydrogel applied as a matrix mixed with a synthetic bone substitute material might lack a sufficient stability over time for this kind of defect.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.12877","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T14:18:49Z","timestamp":1464013129000},"source":"Crossref","is-referenced-by-count":25,"title":["Bone augmentation at peri\u2010implant dehiscence defects comparing a synthetic polyethylene glycol hydrogel matrix vs. standard guided bone regeneration techniques"],"prefix":"10.1111","volume":"28","author":[{"given":"Daniel S.","family":"Thoma","sequence":"first","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ui\u2010Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P.","family":"Bienz","sequence":"additional","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"H\u00fcsler","sequence":"additional","affiliation":[{"name":"Clinic of Fixed and Removable 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