{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:04:10Z","timestamp":1790442250686,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sweden & Martina, Due Carrare, Padua, Italy"},{"name":"ARDEC Academy, Ariminum Odontologica SRL, Rimini, Italy"},{"name":"Clinical Research Foundation (CRF) for the Promotion of Oral Health, CH-3855 Brienz, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the early sequential stages of tissue composition in the cortical and marrow compartments of the alveolar bone crest at implants with a moderately rough surface.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Three month after tooth extraction in 12 Labrador dogs, full\u2010thickness flaps were elevated in the edentulous region of the right side of the mandible and one implant was installed. The flaps were sutured to allow a fully submerged healing. The timing of the installations in the left side of the mandible and of sacrifices were scheduled in such a way to obtained biopsies representing the healing after 5, 10, 20, and 30\u00a0days. Ground sections (<jats:italic>n<\/jats:italic>\u00a0=\u00a06 per each healing period) were prepared, and the percentages of osteoid\/new bone, old bone, new soft tissues (provisional matrix and primitive marrow), mature bone marrow, vessels, and other tissues (bone debris\/particles and clot) were evaluated laterally to the implant surface up to a distance of about 0.4\u00a0mm from it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Osteoid\/new bone was found after 5\u00a0days at percentages of 10.8\u00a0\u00b1\u00a04.3% at the marrow and 0.6\u00a0\u00b1\u00a00.6% at the cortical compartments. After 30\u00a0days, these percentages increased up to 56.4\u00a0\u00b1\u00a04.0% and 23.3\u00a0\u00b1\u00a06.1%, respectively. Old parent bone was resorbed between 5 and 30\u00a0days from 28.7\u00a0\u00b1\u00a010.9% to 14.9\u00a0\u00b1\u00a03.4% at the marrow (~48% of resorption) and from 81.2\u00a0\u00b1\u00a09.4% to 67.6\u00a0\u00b1\u00a05.6% at the cortical (~17% of resorption) compartments. All differences were statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bone apposition to an implant surface followed a significantly different pattern in the compact and the marrow compartments around the implants. While in the compact compartments, bone apposition had to develop through the <jats:styled-content style=\"fixed-case\">BMU<\/jats:styled-content>s following resorption, it developed in very dense layers through an early apposition in the marrow compartments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12913","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T03:42:50Z","timestamp":1467171770000},"page":"1030-1037","source":"Crossref","is-referenced-by-count":14,"title":["Morphometric evaluation of the early stages of healing at cortical and marrow compartments at titanium implants: an experimental study in the dog"],"prefix":"10.1111","volume":"28","author":[{"given":"Marino","family":"Caroprese","sequence":"first","affiliation":[{"name":"Faculty of Dentistry University of Medical Science La Habana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklaus P.","family":"Lang","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine University of Zurich Zurich Switzerland"},{"name":"University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotorial Science University of Bologna Bologna Italy"},{"name":"ARDEC Academy Ariminum Odontologica Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Dental School University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Favero","sequence":"additional","affiliation":[{"name":"ARDEC Academy Ariminum Odontologica Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[{"name":"ARDEC Academy Ariminum Odontologica Rimini Italy"},{"name":"POI \u2013 Programa Odontol\u00f3gico Internacional Cartagena de Indias Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01082.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00972.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02107.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.140101.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.140105.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12872"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12475"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12311"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12719"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12591"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02172.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12533"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12389"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12097"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1973.tb04629.x"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.12913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.12913","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.12913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:40:02Z","timestamp":1696318802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.12913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,28]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/clr.12913"],"URL":"https:\/\/doi.org\/10.1111\/clr.12913","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,28]]}}}