{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:17:39Z","timestamp":1775744259510,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2014R1A1A1A05002953"],"award-info":[{"award-number":["2014R1A1A1A05002953"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The objectives of this study were to evaluate bone regeneration beneath a newly devised bone substitute combined with collagen membrane (called a bone patch) lying over a concomitantly placed mini\u2010implant following sinus floor elevation and verify its usefulness as a carrier system for recombinant human bone morphogenetic protein\u20102 (rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102) in rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The sinus floor elevation procedure was performed bilaterally in five rabbits. Either a plain bone patch (control group) or an rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\u2010loaded patch (experimental group) was randomly placed beneath the elevated sinus membrane (SM) of both sinuses, where the mini\u2010implants were concomitantly placed. Micro\u2010computed tomographic and histologic analyses were performed at 4\u00a0weeks post\u2010surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In micro\u2010computed tomography, the median values of the total augmented volume and the mineralized bone volume were significantly higher in the experimental group than in the control group (161 vs. 122\u00a0mm<jats:sup>3<\/jats:sup> [<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01] and 48 vs. 42\u00a0mm<jats:sup>3<\/jats:sup> [<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05], respectively). Histometric analysis revealed the same outcomes, with new bone areas of 6.41 and 2.97\u00a0mm<jats:sup>2<\/jats:sup> in the experimental and control groups, respectively (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), and bone\u2010to\u2010implant contact ratios of 22.6% and 5.2%, respectively (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The newly devised bone patch in this study can support the elevated <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> and facilitate bone regeneration from the basal bone with a reduced amount of biomaterial. The addition of rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 may shorten the healing time for multidirectional bone regeneration toward the implant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12935","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T06:16:55Z","timestamp":1469686615000},"page":"1175-1181","source":"Crossref","is-referenced-by-count":6,"title":["<i>De novo<\/i> bone formation underneath the sinus membrane supported by a bone patch: a pilot experiment in rabbit sinus model"],"prefix":"10.1111","volume":"28","author":[{"given":"So\u2010Ra","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Kook","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Periodontology 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