{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:23:01Z","timestamp":1793294581819,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T00:00:00Z","timestamp":1482019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Nobel Biocare Services AG","award":["T-186."],"award-info":[{"award-number":["T-186."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare clinical performance of a new resorbable non\u2010cross\u2010linked collagen membrane, creos xenoprotect (<jats:styled-content style=\"fixed-case\">CXP<\/jats:styled-content>), with a reference membrane (<jats:styled-content style=\"fixed-case\">BG<\/jats:styled-content>) for guided bone regeneration at dehisced implant sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This randomized controlled clinical trial enrolled patients with expected dehiscence defects following implant placement to restore single teeth in the maxillary and mandibular esthetic zone and premolar area. Implants were placed using a two\u2010stage surgical protocol with delayed loading. Bone augmentation material placed at the implant surface was immobilized with <jats:styled-content style=\"fixed-case\">CXP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">BG<\/jats:styled-content> membrane. Soft tissue health was followed during the healing period, and the defect size was measured at reentry and 6\u00a0months after implant placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 49 included patients, 24 were treated with <jats:styled-content style=\"fixed-case\">CXP<\/jats:styled-content> and 25 with <jats:styled-content style=\"fixed-case\">BG<\/jats:styled-content>. Patient characteristics did not differ between the two arms. In the <jats:styled-content style=\"fixed-case\">CXP<\/jats:styled-content> arm, the defect height at implant insertion was (mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) 5.1\u00a0\u00b1\u00a02.1\u00a0mm (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) and reduced at reentry by 81% to 1.0\u00a0\u00b1\u00a01.3\u00a0mm (<jats:italic>n<\/jats:italic>\u00a0=\u00a023). In the <jats:styled-content style=\"fixed-case\">BG<\/jats:styled-content> arm, the defect height at implant insertion was 4.9\u00a0\u00b1\u00a01.9\u00a0mm (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) and reduced at reentry by 62% to 1.7\u00a0\u00b1\u00a02.1\u00a0mm (<jats:italic>n<\/jats:italic>\u00a0=\u00a024). Assuming a margin of non\u2010inferiority of 1\u00a0mm, <jats:styled-content style=\"fixed-case\">CXP<\/jats:styled-content> was non\u2010inferior to <jats:styled-content style=\"fixed-case\">BG<\/jats:styled-content>. Membrane exposure rate was highest at week 3 in both arms, reaching 16.7% for <jats:styled-content style=\"fixed-case\">BG<\/jats:styled-content> and 8.7% for <jats:styled-content style=\"fixed-case\">CXP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The new resorbable non\u2010cross\u2010linked collagen membrane facilitates bone gain to support implant placement in expected dehiscence defects. The observed trend toward higher mean bone gain and lower exposure rate with <jats:styled-content style=\"fixed-case\">CXP<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">BG<\/jats:styled-content> should be further investigated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.12995","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T04:48:59Z","timestamp":1482122939000},"source":"Crossref","is-referenced-by-count":42,"title":["A multicenter randomized controlled clinical trial using a new resorbable non\u2010cross\u2010linked collagen membrane for guided bone regeneration at dehisced single implant sites: interim results of a bone augmentation procedure"],"prefix":"10.1111","volume":"28","author":[{"given":"Bastian","family":"Wessing","sequence":"first","affiliation":[{"name":"Private Clinic Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Urban","sequence":"additional","affiliation":[{"name":"Graduate Implant Dentistry Loma Linda CA USA"},{"name":"Urban Regeneration Institute Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Montero","sequence":"additional","affiliation":[{"name":"Section\u00a0of Graduate Periodontology Faculty of Odontology University Complutense of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Zechner","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery University Clinic of Dentistry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hof","sequence":"additional","affiliation":[{"name":"Division of Dental Student Training and Patient Care Department of Oral Surgery University Clinic of Dentistry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Al\u00e1ndez Chamorro","sequence":"additional","affiliation":[{"name":"Private Clinic Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Al\u00e1ndez Martin","sequence":"additional","affiliation":[{"name":"Private Clinic Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Polizzi","sequence":"additional","affiliation":[{"name":"Private Clinic BSC Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Meloni","sequence":"additional","affiliation":[{"name":"Dentistry Unit Department of Surgical Microsurgical, and Medical Sciences University Hospital of Sassari Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Section\u00a0of Graduate Periodontology Faculty of Odontology University Complutense of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,18]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"49","article-title":"Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement?","volume":"22","author":"Aghaloo T.L.","year":"2007","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00642.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01315.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01689.x"},{"key":"e_1_2_9_6_1","first-page":"31","article-title":"The use of e\u2010PTFE barrier membranes for bone promotion around titanium implants placed into extraction sockets: a prospective multicenter study","volume":"9","author":"Becker W.","year":"1994","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12284"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.1999.tb00086.x"},{"key":"e_1_2_9_9_1","first-page":"1","article-title":"Osseointegrated implants in the treatment of the edentulous jaw. 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