{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:33:58Z","timestamp":1783744438016,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T00:00:00Z","timestamp":1487376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Yantai Scientific Development Foundation","award":["2013ws251"],"award-info":[{"award-number":["2013ws251"]}]},{"name":"Taishan Oversea Expert Foundation","award":["tshw20120233"],"award-info":[{"award-number":["tshw20120233"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to perform a histomorphometric evaluation of the healing characteristics and jawbone remodeling processes in the peri\u2010implant bone tissue of three commonly used implant surfaces, during the early weeks of osseointegration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Dental implants with three different surfaces (anodically modified, hydroxyapatite (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>)\u2010coated and machined) were inserted into the mandibular side\u2010tooth region of twelve adult mini\u2010pigs. Histomorphometric analyses were performed to evaluate remodeling processes 3, 6 and 12\u00a0weeks post\u2010implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only a few very early bone remodeling\u2013resorption sites were found at 3\u00a0weeks. After 6\u00a0weeks, additional signs of remodeling\u2010related reversal and bone formation were detectable in all three groups, which steadily increased until 12\u00a0weeks. At the latter time point, the amount of remodeled bone was significantly higher for the anodized and <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\u2010coated surfaces than for the machined implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study demonstrate that peri\u2010implant bone remodeling can start as early as 3\u00a0weeks after implantation and continues at a substantial level up to 12\u00a0weeks. The anodic modification or <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> coating of implant surfaces appears to accelerate the conversion of primary regenerated bone into more mature secondary lamellar bone. 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