{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:31:30Z","timestamp":1792477890446,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effect of leukocyte and platelet\u2010rich fibrin (L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>) in combination with deproteinized bovine bone mineral (<jats:styled-content style=\"fixed-case\">DBBM<\/jats:styled-content>) on bone regeneration in maxillary sinus augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Thirteen patients (nine males and four females, mean age\u00a0\u00b1\u00a0<jats:italic>SD<\/jats:italic>; 49.92\u00a0\u00b1\u00a010.37) were enrolled to the study. 26 maxillary sinus augmentation procedures were randomly performed using <jats:styled-content style=\"fixed-case\">DBBM<\/jats:styled-content> and L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> mixture (test) or <jats:styled-content style=\"fixed-case\">DBBM<\/jats:styled-content> alone (control) in a split\u2010mouth design. The same surgical procedures were performed in both groups, and bone biopsies were harvested from the implant sites 6\u00a0months postoperatively for histological and histomorphometric evaluations as the primary outcome of the study. Implants were placed and then loaded in the augmented sites after 6\u00a0months. The secondary outcomes included clinical and radiographic data and were obtained pre\u2010 and postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no qualitative difference in histological analyses among the groups. In all samples, a newly formed bone was in direct contact with the residual material. The percentages of newly formed bone (test; 21.38\u00a0\u00b1\u00a08.78% and control; 21.25\u00a0\u00b1\u00a05.59%), residual bone graft (test; 25.95\u00a0\u00b1\u00a09.54% and control; 32.79\u00a0\u00b1\u00a05.89%), bone graft in contact with the newly formed bone (test; 47.33\u00a0\u00b1\u00a012.33% and control; 54.04\u00a0\u00b1\u00a08.36%), and soft tissue (test; 52.67\u00a0\u00b1\u00a012.53% and control; 45.96\u00a0\u00b1\u00a08.36%) were similar among the groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Similar radiographic bone height in the augmented area was observed, and implant survival rate was 100% for both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both techniques were effective for maxillary sinus augmentation, and after 6\u00a0months of healing, the addition of L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">DBBM<\/jats:styled-content> did not improve the amount of regenerated bone or the amount of the graft integrated into the newly formed bone under histological and histomorphometric evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13044","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T10:16:37Z","timestamp":1502187397000},"page":"67-75","source":"Crossref","is-referenced-by-count":73,"title":["Maxillary sinus augmentation with leukocyte and platelet\u2010rich fibrin and deproteinized bovine bone mineral: A split\u2010mouth histological and histomorphometric study"],"prefix":"10.1111","volume":"29","author":[{"given":"Nejat","family":"Nizam","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry Ege University  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclnihal","family":"Eren","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Ege University  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9811-0627","authenticated-orcid":false,"given":"Aliye","family":"Akcal\u0131","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Ege University  \u0130zmir Turkey"},{"name":"Centre for Oral Clinical Research Institute of Dentistry, Barts and The London School of Medicine and Dentistry Queen Mary University of London (QMUL)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Donos","sequence":"additional","affiliation":[{"name":"Centre for Oral Clinical Research Institute of Dentistry, Barts and The London School of Medicine and Dentistry Queen Mary University of London (QMUL)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,8]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200001000-00037"},{"key":"e_1_2_8_4_1","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and bone","volume":"38","author":"Boyne P. 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