{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:52:53Z","timestamp":1790949173717,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the clinical and histologic outcomes of two different grafting materials (allograft and xenograft) when combined with autogenous bone and covered with a collagen membrane for sinus augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A parallel case series of fourteen patients in need of a unilateral sinus augmentation was evaluated in this study. Seven patients received a graft composed by autologous cortical bone (ACB) and anorganic bovine bone in a ratio of 1:1; the other seven patients received ACB mixed with an allograft in the same ratio. Bone biopsies were obtained 6\u00a0months after sinus augmentation at the time of implant placement. Comparative histomorphometrical, histopathological, and immunohistochemical analyses were conducted and statistically analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 12\u00a0months of functional loading, all implants in both groups were clinical and radiographically successful. Histomorphometrically, although the initial bone formation was not significantly different between groups (new mineralized tissue: 41.03(12.87)% vs. 34.50(13.18)%, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.620; allograft vs. xenograft groups), the graft resorbed faster in the allograft group (remnant graft particles: 9.83[7.77]% vs. 21.71[17.88]%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.026; allograft vs. xenograft groups). Non\u2010mineralized tissue did not statistically differ either (49.00[14.32]% vs. 43.79[19.90]%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.710; allograft vs. xenograft groups). The histologic analyses revealed higher cellular content, four times more osteoid lines, and higher vascularization in the xenograft group. Musashi\u20101 (mesenchymal stromal cell marker) was also more intensively expressed in the xenograft group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both composite grafts generate adequate substratum to receive dental implants after healing. Compared with the xenograft composite, allograft composite shows faster turnover and a quicker decrease in biological action after 6\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13098","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T08:50:36Z","timestamp":1509007836000},"page":"192-201","source":"Crossref","is-referenced-by-count":43,"title":["Histopathological comparison of healing after maxillary sinus augmentation using xenograft mixed with autogenous bone versus allograft mixed with autogenous bone"],"prefix":"10.1111","volume":"29","author":[{"given":"Pablo","family":"Galindo\u2010Moreno","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry School of Dentistry University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan G.","family":"de Buitrago","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry School of Dentistry University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-1341","authenticated-orcid":false,"given":"Miguel","family":"Padial\u2010Molina","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry School of Dentistry University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Emilio","family":"Fern\u00e1ndez\u2010Barbero","sequence":"additional","affiliation":[{"name":"Department of Anatomy School of Medicine University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ata\u2010Ali","sequence":"additional","affiliation":[{"name":"Public Dental Health Service, Arnau de Vilanova Hospital &amp; Department of Dentistry European University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"O\u2032Valle","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Institute of Biopathology and Regenerative Medicine (IBIMER, CIBM) University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12694"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3181e59b32"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090686"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01936.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01502.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1973.0019"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01733.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12702"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12402"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.0022-0337.2003.67.8.tb03681.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3180de4c5f"},{"key":"e_1_2_9_13_1","first-page":"543","article-title":"Comparison of mineralized cancellous bone allograft (Puros) and anorganic bovine bone matrix (Bio\u2010Oss) for sinus augmentation: Histomorphometry at 26 to 32\u00a0weeks after grafting","volume":"26","author":"Froum S. 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