{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:20:59Z","timestamp":1790828459887,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effect of resorbable membranes on one\u2010stage ridge augmentation procedures in small (2\u20104\u00a0mm) buccal bony dehiscences in anterior maxillary single\u2010tooth replacement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Patients with a buccal bony dehiscence after implant placement in the esthetic zone were randomly allocated to one\u2010stage ridge augmentation with (M+) or without a membrane (M\u2212). Second\u2010phase surgery was performed after 8\u00a0weeks, and follow\u2010up was performed 1, 6, and \u226512\u00a0months after loading. Outcomes included implant survival and success, complications, clinical and radiographic parameters, esthetic results and patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two patients were randomized to one\u2010stage ridge augmentation with (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) or without use of a membrane (<jats:italic>n<\/jats:italic>\u00a0=\u00a027). No significant differences in implant survival and success have been observed. The risk of having a small mucosal dehiscence was more than six times higher in the M+ group than in the M\u2212 group (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 6.24, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.81 to 48.21). At the last follow\u2010up, the bleeding index (<jats:styled-content style=\"fixed-case\">BI<\/jats:styled-content>) was marginally higher in the M+ group (14\/9\/2\/0) compared to the M\u2010 group (24\/2\/0\/0) (<jats:italic>U\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>205, <jats:italic>Z\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>\u22122.97, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.003, <jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.42). The median change in marginal bone level was statistically lower in the M+ group (0.06\u00a0mm) than the M\u2212 group (0.60\u00a0mm) at last follow\u2010up (<jats:italic>U\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>120, <jats:italic>Z\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>\u22122.73 a <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.006 <jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.42). Total pink esthetic index (<jats:styled-content style=\"fixed-case\">PES<\/jats:styled-content>) and white esthetic score (<jats:styled-content style=\"fixed-case\">WES<\/jats:styled-content>) and combined <jats:styled-content style=\"fixed-case\">PES<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">WES<\/jats:styled-content> were not significantly different between treatment groups at more than 12\u00a0months after loading. Only the subcategory root convexity\/soft tissue color scored significantly lower in the M+ group (1.5) compared to the M\u2212 group (2.0) at the last follow\u2010up (<jats:italic>U\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>172, <jats:italic>Z\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>\u22122.34, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.019 <jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.34). No differences were found in patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of a resorbable membrane in small buccal bony dehiscences in anterior maxillary single\u2010tooth replacement resulted in less marginal bone loss, but showed more mucosal dehiscences, higher bleeding scores and lower scores on root convexity and soft tissue color after at least one year of loading. No effect was seen on implant survival and success, overall esthetic results, and patient satisfaction.<\/jats:p><jats:p>The research protocol was registered at the Dutch Trial Register (<jats:styled-content style=\"fixed-case\">NTR<\/jats:styled-content>) with <jats:styled-content style=\"fixed-case\">ID NTR<\/jats:styled-content>6137.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13106","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T04:03:32Z","timestamp":1513742612000},"page":"235-247","source":"Crossref","is-referenced-by-count":10,"title":["The effect of resorbable membranes on one\u2010stage ridge augmentation in anterior single\u2010tooth replacement: A randomized, controlled clinical trial"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0100-3871","authenticated-orcid":false,"given":"Brend P.","family":"Jonker","sequence":"first","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Special Dental Care and Orthodontics Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eppo B.","family":"Wolvius","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Special Dental Care and Orthodontics Erasmus University Medical Center  Rotterdam The Netherlands"},{"name":"St. Anna Hospital  Geldrop The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"van der Tas","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Special Dental Care and Orthodontics Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Pijpe","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Special Dental Care and Orthodontics Erasmus University Medical Center  Rotterdam The Netherlands"},{"name":"Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"11","article-title":"The long\u2010term efficacy of currently used dental implants: A review and proposed criteria of success","volume":"1","author":"Albrektsson T.","year":"1986","journal-title":"The International journal of oral & maxillofacial implants"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080435"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01583.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012001026.x"},{"key":"e_1_2_6_6_1","first-page":"43","article-title":"Optmizing esthetics for implant restaurations in the anterior maxilla: Anatomic an surgical considerations","volume":"19","author":"Buser D.","year":"2004","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1990.010105.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100408"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01781.x"},{"key":"e_1_2_6_10_1","first-page":"91","article-title":"The longitudinal clinical efficacy of osseointegrated dental implants: A 3\u2010year report","volume":"2","author":"Cox J. F.","year":"1987","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.74.3.0487"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1991.020401.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198805000-00004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01269.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12171"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01193.x"},{"key":"e_1_2_6_17_1","first-page":"113","article-title":"Influence of the 3\u2010d bone\u2010to\u2010implant relationship on esthetics","volume":"25","author":"Grunder U.","year":"2005","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1998.tb00132.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758736012456543"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01622.x"},{"key":"e_1_2_6_21_1","volume-title":"Cochrane handbook for systematic reviews of interventions version 5.1.0 (updated march 2011)","author":"Higgings J. P.","year":"2011"},{"key":"e_1_2_6_22_1","first-page":"335","article-title":"The clinical value of membranes in bone augmentation procedures in oral implantology: A systematic review of randomised controlled trials","volume":"9","author":"Jonker B. P.","year":"2016","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12296"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2013.4202"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.00983.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g1.1"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3182181d3d"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.5.646"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01523.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12811"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c869"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00008.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1987.tb00298.x"},{"key":"e_1_2_6_35_1","first-page":"107","article-title":"Gingival sulcus bleeding\u2013a leading symptom in initial gingivitis","volume":"15","author":"M\u00fchlemann H.","year":"1971","journal-title":"Helvetica Odontologica Acta"},{"key":"e_1_2_6_36_1","first-page":"9","article-title":"Bone regeneration adjacent to titanium dental implants using guided tissue regeneration. A report of 2 cases","volume":"5","author":"Nyman S.","year":"1990","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01207.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01408.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01094.x"},{"key":"e_1_2_6_40_1","first-page":"435","article-title":"A randomized, controlled clinical evaluation of a synthetic gel membrane for guided bone regeneration around dental implants: Clinical and radiologic 1\u2010 and 3\u2010year results","volume":"27","author":"Ramel C. F.","year":"2012","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_41_1","first-page":"231","volume-title":"The handbook of research synthesis","author":"Rosenthal R","year":"1994"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02486.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2000.5.1.119"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12339"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12517"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02279.x"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.13106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.13106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T13:25:27Z","timestamp":1695043527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.13106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,19]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/clr.13106"],"URL":"https:\/\/doi.org\/10.1111\/clr.13106","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,19]]}}}