{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:00:55Z","timestamp":1789826455357,"version":"4.0.1"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T00:00:00Z","timestamp":1514592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"International Team for Implantology - ITI","award":["858_2012"],"award-info":[{"award-number":["858_2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the bone response to a two\u2010piece zirconia implant in comparison with a control titanium implant in the canine mandible 4 and 16\u00a0weeks after restoration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Zirconia and titanium implants were alternately placed bilaterally in healed mandibular molar and premolar sites of five canines. Full\u2010ceramic single\u2010tooth restorations were cemented after 6\u00a0weeks of transmucosal healing, allowing for full functional loading of the implants. Histologic and histometric analyses were performed on orofacial and mesiodistal undecalcified sections of the specimens obtained upon sacrifice after 4 and 16\u00a0weeks of functional loading. Bone\u2010to\u2010implant contact (<jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content>), multinucleated giant cells\u2010to\u2010implant contact (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>), crestal bone level, and peri\u2010implant bone density were histometrically assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 60 implants and 60 restorations were still in function after 4 and 16\u00a0weeks of loading in both test and control groups. No implant loss, no implant or abutment fracture, and no chipping of the restorations could be detected. Histometric analysis showed no statistically significant differences between zirconia and titanium implants in <jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content>, crestal bone level, and peri\u2010implant bone density at both time points. Between 4 and 16\u00a0weeks, the crestal bone level around zirconia implants showed a small but statistically significant increase in its distance from the implant shoulder. <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> was very low on both implant types and both time points and decreased statistically significantly overtime.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present two\u2010piece zirconia implant showed a similar bone integration compared to the titanium implant with similar surface morphology after 4 and 16\u00a0weeks of loading.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13112","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T06:58:35Z","timestamp":1514617115000},"page":"277-289","source":"Crossref","is-referenced-by-count":42,"title":["Bone response to functionally loaded, two\u2010piece zirconia implants: A preclinical histometric study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-6863","authenticated-orcid":false,"given":"Simone F. M.","family":"Janner","sequence":"first","affiliation":[{"name":"Department of Periodontics University of Texas Health Science Center at San Antonio  San Antonio TX USA"},{"name":"Department of Oral Surgery and Stomatology School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gahlert","sequence":"additional","affiliation":[{"name":"Clinic for Oral and Cranio\u2010Maxillofacial Surgery Hightech Research Center University Hospital Basel University of Basel  Basel Switzerland"},{"name":"Private Practice  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter D.","family":"Bosshardt","sequence":"additional","affiliation":[{"name":"Robert K. 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