{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:04:51Z","timestamp":1790442291582,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF\u20102017R1A2B2002537"],"award-info":[{"award-number":["NRF\u20102017R1A2B2002537"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study was to determine the effect of bone morphogenetic protein\u20102 (<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102) mixed with either polyethylene glycol hydrogel or synthetic bone substitute (<jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>) on new bone formation in peri\u2010implant dehiscence defects after 16\u00a0weeks of healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A guided bone regeneration procedure was performed in box\u2010type peri\u2010implant defects that were surgically prepared in six beagle dogs. The following four experimental groups were used (i) control (no graft), (ii) <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>+hydrogel, (iii) <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/hydrogel and (iv) <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>+hydrogel. Volumetric analysis using micro\u2010computed tomography and histomorphometric analysis was performed at 16\u00a0weeks post\u2010operatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The amount of new bone and the total augmented volume did not differ significantly between both <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u2010treated groups and the <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>+hydrogel group (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05). Likewise, no histometric differences were observed in the values of new bone area and bone\u2010to\u2010implant contact ratio among the three augmentation groups (new bone area: 0.06\u00a0\u00b1\u00a00.08, 0.19\u00a0\u00b1\u00a00.20, 0.48\u00a0\u00b1\u00a00.37 and 0.56\u00a0\u00b1\u00a00.60\u00a0mm<jats:sup>2<\/jats:sup> [mean\u00a0\u00b1\u00a0standard deviation] in groups\u00a01\u20134, respectively; bone\u2010to\u2010implant contact: 9.44\u00a0\u00b1\u00a011.51%, 19.91\u00a0\u00b1\u00a015.19%, 46.31\u00a0\u00b1\u00a029.82% and 42.58\u00a0\u00b1\u00a026.27% in groups\u00a01\u20134, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The osteogenic efficacy of <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 on the regeneration of peri\u2010implant bone defects was not detectable after 16\u00a0weeks regardless of the carrier materials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13117","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T14:08:40Z","timestamp":1516198120000},"page":"300-308","source":"Crossref","is-referenced-by-count":17,"title":["Osteogenic efficacy of <scp>BMP<\/scp>\u20102 mixed with hydrogel and bone substitute in peri\u2010implant dehiscence defects in dogs: 16\u00a0weeks of healing"],"prefix":"10.1111","volume":"29","author":[{"given":"Jae\u2010Kook","family":"Cha","sequence":"first","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4172","authenticated-orcid":false,"given":"Ui\u2010Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-7447","authenticated-orcid":false,"given":"Daniel S.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Department of Fixed and Removable Prosthodontics and Dental Material Science Dental School University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph H. F.","family":"H\u00e4mmerle","sequence":"additional","affiliation":[{"name":"Department of Fixed and Removable Prosthodontics and Dental Material Science Dental School University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-1320","authenticated-orcid":false,"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Fixed and Removable Prosthodontics and Dental Material Science Dental School University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4036(200010)42:6<663::AID-BIMJ663>3.0.CO;2-7"},{"key":"e_1_2_7_3_1","first-page":"29","article-title":"Localized ridge augmentation using guided bone regeneration. 1. Surgical procedure in the maxilla","volume":"13","author":"Buser D.","year":"1993","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(01)00398-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2007.03.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2001.tb00142.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.14.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070105.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01257.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01324.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01342.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01634.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01633.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12491"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01270.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01431.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01228.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.02.010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12223"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00551-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.4.512"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515594780"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.05.025"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12989"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100161"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12877"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.00971.x"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.13117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.13117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T13:04:54Z","timestamp":1695647094000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.13117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,17]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/clr.13117"],"URL":"https:\/\/doi.org\/10.1111\/clr.13117","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,17]]}}}