{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:30:58Z","timestamp":1788989458939,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"S16","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this systematic review was to investigate the association between the intake of systemic medications that may affect bone metabolism and their subsequent impact on implant failures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Electronic and manual literature searches were conducted. Implant failure (IF) was the primary outcome, while biological\/mechanical and the causes\/timing associated with IF were set as secondary outcomes. Meta\u2010analyses for the binary outcome IF and odds ratio were performed to investigate the association with medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A final selection of 17 articles was screened for qualitative assessment. As such, five studies focused on evaluating the association of implant failure and non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs), two on selective serotonin reuptake inhibitors (SSRIs), two on proton pump inhibitors (PPIs), seven on bisphosphonates (BPs), and one on anti\u2010hypertensives (AHTNs). For PPIs, the fixed effect model estimated a difference of IF rates of 4.3%, indicating significantly higher IF rates in the test compared to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.5). Likewise, for SSRIs, the IF was shown to be significantly higher in the individuals taking SSRIs (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.5) as estimated a difference of 7.5%. No subset meta\u2010analysis could be conducted for AHTNs medications as only one study fulfilled the inclusion criteria, which revealed an increased survival rate of AHTN medication. None of the other medications yielded significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present systematic review showed an association of PPIs and SSRIs with an increased implant failure rate. Hence, clinicians considering implant therapy should be aware of possible medication\u2010related implant failures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.13137","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T04:11:46Z","timestamp":1539749506000},"page":"55-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Medication\u2010related dental implant failure: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1227-7587","authenticated-orcid":false,"given":"Vivianne","family":"Chappuis","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Stomatology School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-0201","authenticated-orcid":false,"given":"Gustavo","family":"Avila\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Department of Periodontics College of Dentistry University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio G.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Dentistry State University of Maringa  Maringa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8292-1927","authenticated-orcid":false,"given":"Alberto","family":"Monje","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Stomatology School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"e_1_2_8_1_2_1","first-page":"185","article-title":"Influence of ibuprofen on bone healing around dental implants: A randomised double\u2010blind placebo\u2010controlled clinical study","volume":"2","author":"Alissa R.","year":"2009","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_8_1_3_1","first-page":"328","article-title":"Osteoporosis and bisphosphonate\u2010related osteonecrosis in a dental school implant patient population","volume":"24","author":"Al\u2010Sabbagh M.","year":"2015","journal-title":"Implant Dentistry"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040606"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808063390607"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2011.09.003"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61163-1"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3769"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12056"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517737755"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12485"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.01.016"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028016665641"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650111017"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22478"},{"key":"e_1_2_8_1_16_1","first-page":"E106","article-title":"Survival of dental implants among post\u2010menopausal female dental school patients taking oral bisphosphonates: A retrospective study","volume":"32","author":"Famili P.","year":"2011","journal-title":"Compendium of Continuing Education in Dentistry (Jamesburg, NJ: 1995)"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-5751-12-12"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.09.019"},{"key":"e_1_2_8_1_19_1","first-page":"1376","article-title":"Effect of gastric acid secretion on intestinal phosphate and calcium absorption in normal subjects","volume":"10","author":"Graziani G.","year":"1995","journal-title":"Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association \u2013 European Renal Association"},{"key":"e_1_2_8_1_20_1","first-page":"133","article-title":"Skeletal effects of serotonin (5\u2010hydroxytryptamine) transporter inhibition: Evidence from clinical studies","volume":"8","author":"Haney E. 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