{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:30:15Z","timestamp":1767162615245,"version":"build-2238731810"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University of Amsterdam for the stimulation of the research priority area Oral Regenerative Medicine"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n Synthetic biphasic calcium phosphate (\n BCP<\/jats:styled-content>\n ) with a hydroxyapatite\/\u00df\u2010tricalcium phosphate (\n HA<\/jats:styled-content>\n \/\u00df\u2010\n TCP<\/jats:styled-content>\n ) ratio of 60\/40 (\n BCP<\/jats:styled-content>\n 60\/40) is successfully used as alternative for autologous bone in patients undergoing maxillary sinus floor elevation (\n MSFE<\/jats:styled-content>\n ) for dental implant placement. A high percentage of\n HA<\/jats:styled-content>\n in\n BCP<\/jats:styled-content>\n 60\/40 may hamper efficient scaffold remodeling. Osteogenesis and neovascularization are pivotal in effective bone regeneration. We aimed to investigate whether differences exist in osteogenic and\/or vasculogenic potential of\n BCP<\/jats:styled-content>\n 60\/40 and\n BCP<\/jats:styled-content>\n 20\/80 in patients undergoing\n MSFE<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n Twenty patients undergoing\n MSFE<\/jats:styled-content>\n were treated with\n BCP<\/jats:styled-content>\n 60\/40 (\n n<\/jats:italic>\n \u00a0=\u00a010) or\n BCP<\/jats:styled-content>\n 20\/80 (\n n<\/jats:italic>\n \u00a0=\u00a010). Bone and graft volumes were determined by micro\u2010computed tomography and histomorphometrical analysis of biopsies of the augmented region. Osteoid volumes, number of osteoclasts, and blood vessels were determined by histomorphometrical analysis. The biopsies were taken 6.5\u00a0months (26\u00a0weeks) postoperatively prior to dental implant placement.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Bone and osteoid volumes were 9.7% and 0.8% higher at the most cranial side of the\n BCP<\/jats:styled-content>\n 20\/80 biopsies compared to the\n BCP<\/jats:styled-content>\n 60\/40 biopsies. Graft volumes, number of osteoclasts, and blood vessels were similar in both groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n BCP<\/jats:styled-content>\n 20\/80 showed enhanced osteogenic potential in patients undergoing\n MSFE<\/jats:styled-content>\n compared to\n BCP<\/jats:styled-content>\n 60\/40, due to either a faster bone remodeling rate or an earlier start of bone formation in\n BCP<\/jats:styled-content>\n 20\/80\u2010treated patients, suggesting that a higher\n TCP<\/jats:styled-content>\n content positively contributes to the bone remodeling rate. Therefore,\n BCP<\/jats:styled-content>\n 20\/80 might perform better, at least in the short term, as a scaffold for bone augmentation in the\n MSFE<\/jats:styled-content>\n model than\n BCP<\/jats:styled-content>\n 60\/40 as more bone is formed, and more osteoid is deposited at the cranial side in\n BCP<\/jats:styled-content>\n 20\/80\u2010treated patients compared to\n BCP<\/jats:styled-content>\n 60\/40\u2010treated patients. However, catch\u2010up of\n BCP<\/jats:styled-content>\n 60\/40 in the long term cannot be ruled out.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/clr.13146","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T07:43:47Z","timestamp":1523432627000},"page":"488-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of a new biphasic calcium phosphate for maxillary sinus floor elevation: Micro\u2010CT and histomorphometrical analyses"],"prefix":"10.1111","volume":"29","author":[{"given":"Marco N.","family":"Helder","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery VU University Medical Center\/Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam Movement Sciences Amsterdam The Netherlands"},{"name":"Department of Orthopedic Surgery VU University Medical Center Amsterdam Movement Sciences Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9350-2717","authenticated-orcid":false,"given":"Fransisca A. S.","family":"van Esterik","sequence":"additional","affiliation":[{"name":"Department of Oral Cell Biology Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam Movement Sciences Amsterdam The Netherlands"},{"name":"Department of Dental Materials Science Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam Movement Sciences Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mardi D.","family":"Kwehandjaja","sequence":"additional","affiliation":[{"name":"Department of Oral Cell Biology Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam Movement Sciences Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiaan M.","family":"ten Bruggenkate","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery VU University Medical Center\/Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam Movement Sciences Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7661-199X","authenticated-orcid":false,"given":"Jenneke","family":"Klein\u2010Nulend","sequence":"additional","affiliation":[{"name":"Department of Oral Cell Biology Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam Movement Sciences Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Engelbert A. 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M.","family":"Schulten","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery VU University Medical Center\/Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam Movement Sciences Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1945-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12702"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.08.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2012.0404"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01821.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00317-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/7\/1\/015005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00251.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31271"},{"key":"e_1_2_6_11_1","volume-title":"ITI treatment guide, sinus floor elevation procedures, 5","author":"Katsuyama H.","year":"2011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2009.0558"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2013.12.001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1166\/sam.2014.2073"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0267-6605(93)90049-D"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1724-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650020617"},{"key":"e_1_2_6_18_1","first-page":"527","volume-title":"Romeis microscopic technique","author":"Plenk H.","year":"1989"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1681"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0369"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02431.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v025a16"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.01099.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(22)02107-3"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/34.10.3745910"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1934270"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.328"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.32984"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003600107"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.05.003"},{"key":"e_1_2_6_31_1","first-page":"259","article-title":"Pre\u2010implantation surgery of the atrophied maxilla. 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