{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:10:36Z","timestamp":1789495836893,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,27]],"date-time":"2018-05-27T00:00:00Z","timestamp":1527379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Nobel Biocare Services AG","award":["2012-1135"],"award-info":[{"award-number":["2012-1135"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To volumetrically compare peri\u2010implant mid\u2010facial soft tissue changes in immediately placed and provisionalized implants in the aesthetic zone, with or without a connective tissue graft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Sixty patients were included. All implants were placed immediately after extraction. After randomization, in one group, a connective tissue graft (test group, <jats:italic>n<\/jats:italic>\u00a0=\u00a030) was inserted at the buccal aspect of the implant. The other group (control group, <jats:italic>n<\/jats:italic>\u00a0=\u00a030) received no connective tissue graft. Clinical parameters, digital photographs and conventional impressions were obtained before extraction (<jats:italic>T<\/jats:italic><jats:sub>pre<\/jats:sub>) and at 12\u00a0months following definitive crown placement (<jats:italic>T<\/jats:italic><jats:sub>12<\/jats:sub>). The casts were digitized by a laboratory scanner, and a volumetric analysis was performed between <jats:italic>T<\/jats:italic><jats:sub>pre<\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub>12<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five patients in each group were available for analysis at <jats:italic>T<\/jats:italic><jats:sub>12<\/jats:sub>. Volumetric change, transformed to a mean (\u00b1<jats:italic>SD<\/jats:italic>) change in thickness, was \u22120.68\u00a0\u00b1\u00a00.59\u00a0mm (test) and \u22120.49\u00a0\u00b1\u00a00.54\u00a0mm (control) with a non\u2010significant difference between groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.189). The mid\u2010facial mucosa level was significantly different between both groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.014), with a mean (\u00b1<jats:italic>SD<\/jats:italic>) change of +0.20\u00a0\u00b1\u00a00.70\u00a0mm (test) and \u22120.48\u00a0\u00b1\u00a01.13\u00a0mm (control). The Pink Esthetic Score was similar between both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of a <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content> in immediately placed and provisionalized implants in the aesthetic zone did not result in less mucosal volume loss after 12\u00a0months, leading to the assumption that a <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content> cannot fully compensate for the underlying facial bone loss, although a significantly more coronally located mid\u2010facial mucosa level was found when a <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content> was performed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13258","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T03:30:28Z","timestamp":1527478228000},"page":"671-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Immediate placement and provisionalization of implants in the aesthetic zone with or without a connective tissue graft: A 1\u2010year randomized controlled trial and volumetric study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3687-0572","authenticated-orcid":false,"given":"Wouter G.","family":"van Nimwegen","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry M.","family":"Raghoebar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-8798","authenticated-orcid":false,"given":"Elise G.","family":"Zuiderveld","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-1320","authenticated-orcid":false,"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Fixed and Removable Prosthodontics and Dental Material Science School of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-6031","authenticated-orcid":false,"given":"Henny J. A.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen, University of Groningen  Groningen The Netherlands"},{"name":"Department of Implant Dentistry Dental School University Medical Center Groningen, University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1253-1813","authenticated-orcid":false,"given":"Sven","family":"M\u00fchlemann","sequence":"additional","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science Center of Dental Medicine  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"125","article-title":"Thickness of the anterior maxillary facial bone wall \u2013 A retrospective radiographic study using cone beam computed tomography","volume":"2","author":"Braut V.","year":"2011","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513506713"},{"key":"e_1_2_8_4_1","first-page":"186","article-title":"Clinical and esthetic outcomes of implants placed in postextraction sites","volume":"24","author":"Chen S. 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