{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:52:09Z","timestamp":1791841929575,"version":"4.3.4"},"reference-count":87,"publisher":"Wiley","issue":"S18","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Danish Innovation Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n A considerable portion of the adult population has received and\/or is receiving treatment with antiresorptive drugs (\n ARD<\/jats:styled-content>\n s). It is thus relevant to assess possible side effects of\n ARD<\/jats:styled-content>\n intake in connection to various aspects of implant therapy. The aim of this study was to answer the focused question \u201cIn patients with systemic intake of\n ARD<\/jats:styled-content>\n s, what is the outcome and complication rate of implant therapy including associated bone grafting procedures comparing to patients without systemic intake of\n ARD<\/jats:styled-content>\n s?\u201d\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Original studies fulfilled predefined inclusion criteria (e.g., case series, cohort studies, case\u2013control studies, and controlled and\/or randomized controlled clinical trials; retro\u2010 or prospective design; and \u226510 patients with systemic intake of\n ARD<\/jats:styled-content>\n s). Various patient\u2010, medication\u2010, and intervention\u2010related parameters [i.e., implant loss, grafting procedure complication\/failure, peri\u2010implant marginal bone levels\/loss, medication\u2010related osteonecrosis of the jaws (\n MRONJ<\/jats:styled-content>\n ), and peri\u2010implantitis] were extracted, and meta\u2010analyses and quality assessment were performed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty\u2010four studies with bisphosphonate (\n BP<\/jats:styled-content>\n ) intake (mainly low dose for osteoporosis treatment) and seven studies on hormone replacement therapy (\n HRT<\/jats:styled-content>\n ), including \u226510 patients, and controls not taking the medication were identified. Furthermore, seven studies on\n MRONJ<\/jats:styled-content>\n associated with implants were included. Meta\u2010analyses based on four studies reporting on patient level and eight studies reporting on implant level showed no significant differences in terms of implant loss between patients on\n BP<\/jats:styled-content>\n s (mainly low dose for osteoporosis treatment) and controls. Furthermore, low\u2010dose\n BP<\/jats:styled-content>\n intake did not compromise peri\u2010implant marginal bone levels. Based on two studies, no negative effect of\n HRT<\/jats:styled-content>\n was observed on the implant level, while\n HRT<\/jats:styled-content>\n appeared to exert a marginally significant negative effect regarding implant survival on the patient level and regarding peri\u2010implant marginal bone levels. Based on six studies reporting single\u2010patient data,\n MRONJ<\/jats:styled-content>\n in patients on\n BP<\/jats:styled-content>\n for osteoporosis appeared in 70% of the cases >36\u00a0months after start of drug intake, while in patients with cancer,\n MRONJ<\/jats:styled-content>\n appeared in 64% of the cases \u226436\u00a0months after first\n BP<\/jats:styled-content>\n intake.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Low\u2010dose oral\n BP<\/jats:styled-content>\n intake for osteoporosis treatment, in general, does not compromise implant therapy, that is, patients on\n ARD<\/jats:styled-content>\n s do not lose more implants nor get more implant\u2010related complications\/failures comparing to implant patients without\n BP<\/jats:styled-content>\n intake. There is almost no information available on the possible effect on implant therapy of high\u2010dose\n BP<\/jats:styled-content>\n s or other widely used\n ARD<\/jats:styled-content>\n s (e.g., denosumab), or on the success or safety of bone grafting procedures. Patients with high\u2010dose\n ARD<\/jats:styled-content>\n intake for management of malignancies, patients on oral\n BP<\/jats:styled-content>\n over a longer period of time, and patients with comorbidities should be considered as high\u2010risk patients for\n MRONJ<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/clr.13282","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T01:37:16Z","timestamp":1539221836000},"page":"54-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["The effect of antiresorptive drugs on implant therapy: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-3754","authenticated-orcid":false,"given":"Andreas","family":"Stavropoulos","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Odontology University of Malm\u00f6 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-7943","authenticated-orcid":false,"given":"Kristina","family":"Bertl","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Odontology University of Malm\u00f6 Malm\u00f6 Sweden"},{"name":"Division of Oral Surgery School of Dentistry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Pietschmann","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology and Allergy Research Center of Physiology and Pathophysiology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Pandis","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics School of Dental Medicine Department of Orthodontics University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Schi\u00f8dt","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-2446","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Klinge","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Odontology University of Malm\u00f6 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2017.05.028"},{"key":"e_1_2_6_1_3_1","first-page":"328","article-title":"Osteoporosis and bisphosphonate\u2010related osteonecrosis in a dental school implant patient population","volume":"24","author":"Al\u2010Sabbagh M.","year":"2015","journal-title":"Implant Dentistry"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-14-00195"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12526"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.27515"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.11.020"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.12.040"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.01.022"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00972.x"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.08.043"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12556"},{"key":"e_1_2_6_1_13_1","first-page":"470","article-title":"The effects of age, jaw site, and bone condition on oral implant outcomes","volume":"11","author":"Bryant S. R.","year":"1998","journal-title":"The International Journal of Prosthodontics"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00484-7"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/187153006776056666"},{"key":"e_1_2_6_1_16_1","first-page":"329","article-title":"Bisphosphonates and dental implants: A meta\u2010analysis","volume":"47","author":"Chrcanovic B. R.","year":"2016","journal-title":"Quintessence International"},{"key":"e_1_2_6_1_17_1","first-page":"415","article-title":"Impact of local and systemic factors on additional peri\u2010implant bone loss","volume":"44","author":"Souza J. G.","year":"2013","journal-title":"Quintessence International"},{"key":"e_1_2_6_1_18_1","unstructured":"European Medicines Agency. (2013).PSUR assessment report. Strontium ranelate. EMA\/PRAC\/136656\/2013. Retrieved fromhttp:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Assessment_Report_-_Variation\/human\/000560\/WC500147168.pdf."},{"key":"e_1_2_6_1_19_1","first-page":"E106","article-title":"Survival of dental implants among post\u2010menopausal female dental school patients taking oral bisphosphonates: A retrospective study","volume":"32","author":"Famili P.","year":"2011","journal-title":"The Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060514"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002564"},{"key":"e_1_2_6_1_22_1","unstructured":"Global Osteoporosis Market & Drugs Analysis 2010\u20132015. (2011). Retrieved fromhttp:\/\/www.renub.com\/global-osteoporosis-market-and-drugs-analysis-2010-2015-322-p.php."},{"key":"e_1_2_6_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.09.037"},{"key":"e_1_2_6_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.09.019"},{"key":"e_1_2_6_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-013-0136-1"},{"key":"e_1_2_6_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.037"},{"key":"e_1_2_6_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36060"},{"key":"e_1_2_6_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0708-2"},{"key":"e_1_2_6_1_29_1","first-page":"349","article-title":"Safety of oral bisphosphonates: Controlled studies on alveolar bone","volume":"21","author":"Jeffcoat M. K.","year":"2006","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_1_30_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b15-00385"},{"key":"e_1_2_6_1_31_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/19424396.2009.12222946","article-title":"The prognosis for dental implants placed in patients taking oral bisphosphonates","volume":"37","author":"Kasai T.","year":"2009","journal-title":"Journal of the California Dental Association"},{"key":"e_1_2_6_1_32_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2608"},{"key":"e_1_2_6_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2010.04.002"},{"key":"e_1_2_6_1_34_1","first-page":"184","article-title":"Effects of selected factors on the osseointegration of dental implants","volume":"14","author":"Koszuta P.","year":"2015","journal-title":"Przegla\u031cd Menopauzalny"},{"key":"e_1_2_6_1_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12088"},{"key":"e_1_2_6_1_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00182.x"},{"key":"e_1_2_6_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.09.017"},{"key":"e_1_2_6_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_6_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.09.055"},{"key":"e_1_2_6_1_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4308-5"},{"key":"e_1_2_6_1_41_1","first-page":"1216","article-title":"Oral bisphosphonates: Early endosseous dental implant success and crestal bone changes. A retrospective study","volume":"27","author":"Memon S.","year":"2012","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_1_42_1","first-page":"859","article-title":"Dental implant outcomes in postmenopausal women undergoing hormone replacement","volume":"19","author":"Minsk L.","year":"1998","journal-title":"The Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_6_1_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_6_1_44_1","first-page":"569","article-title":"Dental implant failure rates and associated risk factors","volume":"20","author":"Moy P. K.","year":"2005","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_1_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000001535"},{"key":"e_1_2_6_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.07.012"},{"key":"e_1_2_6_1_47_1","first-page":"203","article-title":"How does the timing of implant placement to extraction affect outcome","volume":"22","author":"Quirynen M.","year":"2007","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_1_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-014-0179-z"},{"key":"e_1_2_6_1_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12097"},{"key":"e_1_2_6_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_6_1_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00150.x"},{"key":"e_1_2_6_1_52_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-13-00063"},{"key":"e_1_2_6_1_53_1","first-page":"225","article-title":"Mechanisms of action of antiresorptive therapies of postmenopausal osteoporosis","volume":"37","author":"Stepan J. J.","year":"2003","journal-title":"Endocrine Regulations"},{"key":"e_1_2_6_1_54_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1864"},{"key":"e_1_2_6_1_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12662"},{"key":"e_1_2_6_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.09.018"},{"key":"e_1_2_6_1_57_1","first-page":"71","article-title":"A retrospective study of 1925 consecutively placed immediate implants from 1988 to 2004","volume":"21","author":"Wagenberg B.","year":"2006","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_1_58_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2809"},{"key":"e_1_2_6_1_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-016-0041-7"},{"key":"e_1_2_6_1_60_1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses","author":"Wells G. A.","year":"2016"},{"key":"e_1_2_6_1_61_1","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1136\/heartjnl-2016-311002","article-title":"Menopausal age, postmenopausal hormone therapy and incident atrial fibrillation","volume":"103","author":"Wong J. A.","year":"2017","journal-title":"Heart"},{"key":"e_1_2_6_1_62_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-17-00015"},{"key":"e_1_2_6_1_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01854.x"},{"key":"e_1_2_6_1_64_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-09-00114"},{"key":"e_1_2_6_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2012.09.012"},{"key":"e_1_2_6_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2008.09.007"},{"key":"e_1_2_6_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2012.9"},{"key":"e_1_2_6_2_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2179"},{"key":"e_1_2_6_2_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-71"},{"key":"e_1_2_6_2_7_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-13-00282"},{"key":"e_1_2_6_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.07.049"},{"key":"e_1_2_6_2_9_1","first-page":"e101","article-title":"Bone density around endosseous implants in patients taking alendronate: A pilot study","volume":"32","author":"Griffiths G. R.","year":"2012","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_6_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12944"},{"key":"e_1_2_6_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.07.008"},{"key":"e_1_2_6_2_12_1","doi-asserted-by":"crossref","first-page":"w13605","DOI":"10.4414\/smw.2012.13605","article-title":"Osteopathology of the jaw associated with bone resorption inhibitors: What have we learned in the last 8 years","volume":"142","author":"Jacobsen C.","year":"2012","journal-title":"Swiss Medical Weekly"},{"key":"e_1_2_6_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2009.06.005"},{"key":"e_1_2_6_2_14_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-09-00132.1"},{"key":"e_1_2_6_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2013.06.011"},{"key":"e_1_2_6_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.07.010"},{"key":"e_1_2_6_2_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-015-0207-4"},{"key":"e_1_2_6_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.01.014"},{"key":"e_1_2_6_2_19_1","first-page":"4","article-title":"Bisphosphonate therapy and dental treatment","volume":"86","author":"Phillips G.","year":"2007","journal-title":"The Journal of the Indiana Dental Association"},{"key":"e_1_2_6_2_20_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-13-00178"},{"key":"e_1_2_6_2_21_1","first-page":"239","article-title":"Bone scintigraphy and osseointegration (preliminary report)","volume":"21","author":"Stvrtecky R. O.","year":"1995","journal-title":"The Journal of Oral Implantology"},{"key":"e_1_2_6_2_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-0951-1"},{"key":"e_1_2_6_2_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12493"},{"key":"e_1_2_6_2_24_1","first-page":"410","article-title":"Do Fosamax\u2010type drugs increase the risk of osteonecrosis of the jaw for patients receiving dental implants","volume":"56","author":"Wynn R. L.","year":"2008","journal-title":"General Dentistry"},{"key":"e_1_2_6_2_25_1","first-page":"31","article-title":"Clinical application of bisphosphonates in implant dentistry: Histomorphometric evaluation","volume":"29","author":"Zuffetti F.","year":"2009","journal-title":"The International Journal of Periodontics & Restorative Dentistry"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.13282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.13282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:28:09Z","timestamp":1775244489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.13282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":87,"journal-issue":{"issue":"S18","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/clr.13282"],"URL":"https:\/\/doi.org\/10.1111\/clr.13282","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"2018-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}