{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:09:51Z","timestamp":1789013391344,"version":"build-2803163510"},"reference-count":103,"publisher":"Wiley","issue":"S16","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>his review evaluated implant survival in geriatric patients (\u226575\u00a0years) and\/or the impact of systemic medical conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Systematic literature searches were performed to identify studies reporting on geriatric subjects with dental implants and on implant patients who had any of the seven most common systematic conditions among geriatric patients. Meta\u2010analyses were performed on the postloading implant survival rates. The impact of systemic medical conditions and their respective treatment was qualitatively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 6,893 studies were identified; of those, 60 studies were included. The fixed\u2010effects model revealed an overall implant survival of 97.3% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 94.3, 98.7; studies\u00a0=\u00a07) and 96.1% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 87.3, 98.9; studies\u00a0=\u00a03), for 1 and 5\u00a0years, respectively. In patients with cardiovascular disease, implant survival may be similar or higher compared to healthy patients. High implant survival rates were reported for patients with Parkinson's disease or diabetes mellitus type\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      . In patients with cancer, implant survival is negatively affected, namely by radiotherapy. Patients with bone metastases receiving high\u2010dose antiresorptive therapy (\n                      <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\n                      ) carry a high risk for complications after implant surgery. Implant survival was reported to be high in patients receiving low\u2010dose\n                      <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\n                      for treatment of osteoporosis. No evidence was found on implant survival in patients with dementia, respiratory diseases, liver cirrhosis, or osteoarthritis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Implant prostheses in geriatric subjects are a predictable treatment option with a very high rate of implant survival. The functional and psychosocial benefits of such intervention should outweigh the associated risks to common medical conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/clr.13288","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T04:11:46Z","timestamp":1539749506000},"page":"311-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":168,"title":["Effect of advanced age and\/or systemic medical conditions on dental implant survival: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-5534","authenticated-orcid":false,"given":"Martin","family":"Schimmel","sequence":"first","affiliation":[{"name":"Division of Gerodontology School of Dental Medicine University of Bern Bern Switzerland"},{"name":"Division of Gerodontology and Removable Prosthodontics University Clinics of Dental Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-576X","authenticated-orcid":false,"given":"Murali","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Division of Gerodontology and Removable Prosthodontics University Clinics of Dental Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-1673","authenticated-orcid":false,"given":"Gerald","family":"McKenna","sequence":"additional","affiliation":[{"name":"Centre for Public Health Queen's University Belfast Institute of Clinical Sciences Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3981-0134","authenticated-orcid":false,"given":"Frauke","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Division of Gerodontology and Removable Prosthodontics University Clinics of Dental Medicine University of Geneva Geneva Switzerland"},{"name":"Department of Internal Medicine, Rehabilitation and Geriatrics University Hospitals of Geneva Th\u00f4nex Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12552"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2010.00324.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01534.x-i2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31828983da"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12477"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(97)70232-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12526"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12133"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/cid.12340","article-title":"Dental implants in an aged population: Evaluation of periodontal health, bone loss, implant survival, and quality of life","volume":"18","author":"Becker W.","year":"2016","journal-title":"Clinical Oral Implants Research"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400407"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.12.040"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g4.1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stomax.2011.01.008"},{"key":"e_1_2_8_15_1","first-page":"12","article-title":"Systemic conditions and treatments as risks for implant therapy","volume":"24","author":"Bornstein M. 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