{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:21:56Z","timestamp":1791645716638,"version":"4.3.4"},"reference-count":6,"publisher":"Wiley","issue":"S16","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of Working Group 4 was to address topics related to biologic risks and complications associated with implant dentistry. Focused questions on (a) diagnosis of peri\u2010implantitis, (b) complications associated with implants in augmented sites, (c) outcomes following treatment of peri\u2010implantitis, and (d) implant therapy in geriatric patients and\/or patients with systemic diseases were addressed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Four systematic reviews formed the basis for discussion in Group 4. Participants developed statements and recommendations determined by group consensus based on the findings of the systematic reviews. These were then presented and accepted following further discussion and modifications as required by the plenary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>) alone is insufficient for the diagnosis of peri\u2010implantitis. The positive predictive value of <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> alone for the diagnosis of peri\u2010implantitis varies and is dependent on the prevalence of peri\u2010implantitis within the population. For patients with implants in augmented sites, the prevalence of peri\u2010implantitis and implant loss is low over the medium to long term. Peri\u2010implantitis treatment protocols which include individualized supportive care result in high survival of implants after 5\u00a0years with about three\u2010quarters of implants still present. Advanced age alone is not a contraindication for implant therapy. Implant placement in patients with cancer receiving high\u2010dose antiresorptive therapy is contraindicated due to the associated high risk for complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diagnosis of peri\u2010implantitis requires the presence of <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> as well as progressive bone loss. Prevalence of peri\u2010implantitis for implants in augmented sites is low. Peri\u2010implantitis treatment should be followed by individualized supportive care. Implant therapy for geriatric patients is not contraindicated; however, comorbidities and autonomy should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13307","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T08:11:46Z","timestamp":1539763906000},"page":"351-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Group 4 ITI Consensus Report: Risks and biologic complications associated with implant dentistry"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-8265","authenticated-orcid":false,"given":"Lisa J.","family":"Heitz\u2010Mayfield","sequence":"first","affiliation":[{"name":"University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"Aaboe","sequence":"additional","affiliation":[{"name":"Private Practice Solrod 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