{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:32:54Z","timestamp":1783362774204,"version":"3.54.6"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Colgate-Palmolive Technology Center, Piscataway, New Jersey, USA","award":["Research Protocol"],"award-info":[{"award-number":["Research Protocol"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effects of a toothpaste containing 0.3% triclosan in volunteers that have been treated for peri\u2010implantitis and were enrolled in a maintenance program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Subjects presenting at least one implant with peri\u2010implantitis were selected. They received anti\u2010infective surgical therapy, and sixty days post\u2010surgery (baseline) were randomized into two groups, brushing twice\/day for 2\u00a0years (a) with a toothpaste containing 0.3% triclosan+2.0% PVM\/MA copolymer (Gantrez<jats:sup>TM<\/jats:sup>)+1,450\u00a0ppm fluoride (test) or (b) with a toothpaste containing 1,450\u00a0ppm fluoride (control). They received clinical and microbiological monitoring at baseline, 3, 6, 12, 18, and 24\u00a0months, and professional maintenance every 3\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 102 subjects were enrolled (test: 48; control: 54). The control group showed loss of clinical attachment (CA) around treated implants over the course of the study (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), while the test group was stable for this parameter. The difference between groups (0.55\u00a0mm) for CA change between baseline and 24\u00a0months (primary outcome variable) was statistically significant (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Red complex pathogens were only reduced in the test group at 24\u00a0months. The implants with no history of peri\u2010implantitis in the test group had a significant reduction in the percentage of sites with bleeding on probing and in mean probing depth, throughout the study (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). This improvement was not observed in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A toothpaste containing 0.3% triclosan was more effective than a toothpaste without triclosan in maintaining a healthy peri\u2010implant environment around treated implants and implants with no history of peri\u2010implantitis during a 2\u2010year maintenance program (ClinicalTrials.govNCT03191721).<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13363","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T02:54:16Z","timestamp":1539744856000},"page":"973-985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of a toothpaste containing 0.3% triclosan in the maintenance phase of peri\u2010implantitis treatment: 2\u2010Year randomized clinical trial"],"prefix":"10.1111","volume":"29","author":[{"given":"Bernal","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of Periodontology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"},{"name":"Colgate\u2010Palmolive Technology Center Piscataway New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil Awad","family":"Shibli","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Araujo","sequence":"additional","affiliation":[{"name":"School of Dentistry State University of Maringa Maringa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene Cristina","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotinos","family":"Panagakos","sequence":"additional","affiliation":[{"name":"Colgate\u2010Palmolive Technology Center Piscataway New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Matarazzo","sequence":"additional","affiliation":[{"name":"School of Dentistry State University of Maringa Maringa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Mairink","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Onuma","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Faveri","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Retamal\u2010Valdes","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-3392","authenticated-orcid":false,"given":"Magda","family":"Feres","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division Guarulhos University Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1736"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1973.tb00756.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080521"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515608832"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12334"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.070672"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12075"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01471.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12049"},{"key":"e_1_2_6_11_1","first-page":"259","article-title":"Efficacy of a triclosan\/NaF dentifrice in the control of plaque and gingivitis and concurrent oral microflora monitoring","volume":"11","author":"Fine D. H.","year":"1998","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00181.x"},{"key":"e_1_2_6_13_1","first-page":"96","article-title":"Evaluation of the antimicrobial activity of dentifrices on human oral bacteria","volume":"21","author":"Haraszthy V. I.","year":"2010","journal-title":"The Journal of Clinical Dentistry"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00348.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g5.3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12910"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01283.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01538.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00513.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02541.x"},{"key":"e_1_2_6_22_1","first-page":"S1","article-title":"Advanced oral antibacterial\/anti\u2010inflammatory technology: A comprehensive review of the clinical benefits of a triclosan\/copolymer\/fluoride dentifrice","volume":"16","author":"Panagakos F. S.","year":"2005","journal-title":"The Journal of Clinical Dentistry"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160184"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1962.0184"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2016.7312"},{"key":"e_1_2_6_26_1","first-page":"103","article-title":"The effect of a triclosan dentifrice on mucositis in subjects with dental implants: A six\u2010month clinical study","volume":"20","author":"Ramberg P.","year":"2009","journal-title":"The Journal of Clinical Dentistry"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010514"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516667484"},{"key":"e_1_2_6_29_1","first-page":"71","article-title":"Group D. Consensus report. Implants\u2013peri\u2010implant (hard and soft tissue) interactions in health and disease: The impact of explosion of implant manufacturers","volume":"17","author":"Shibli J.","year":"2015","journal-title":"Journal of the International Academy of Periodontology"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01566.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280102.x"},{"key":"e_1_2_6_32_1","first-page":"788","article-title":"\"Checkerboard\" DNA\u2010DNA hybridization","volume":"17","author":"Socransky S. S.","year":"1994","journal-title":"BioTechniques"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01617.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12368"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1970.41.1.41"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1987.58.10.706"},{"key":"e_1_2_6_37_1","first-page":"117","article-title":"Analysis of the antibacterial activity and plaque control benefit of colgate total dentifrice via clinical evaluation and real\u2010time polymerase chain reaction","volume":"16","author":"Xu T.","year":"2005","journal-title":"The Journal of Clinical Dentistry"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01274.x"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fclr.13363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/clr.13363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:32:14Z","timestamp":1694932334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/clr.13363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/clr.13363"],"URL":"https:\/\/doi.org\/10.1111\/clr.13363","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"2018-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}