{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:25:09Z","timestamp":1790465109543,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670970"],"award-info":[{"award-number":["31670970"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470780"],"award-info":[{"award-number":["81470780"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the present study was to investigate the effects of strontium\u2010modified implant surfaces on promoting early bone osseointegration in osteoporotic rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The surface topographies, chemical elements, contact angles and ionic releases of the SLA and SLA\u2010Sr samples were analysed by special instruments separately. Sixteen ovariectomized New Zealand rabbits received glucocorticoid administration, and sixteen SHAM rabbits were used as controls. After generating a successful osteoporosis\u2010induced model, SLA and SLA\u2010Sr implants were randomly inserted into the tibia and femur metaphysis of each animal. The rabbits were sacrificed after 3 and 6\u00a0weeks of bone healing, and then, removal torque values (RTVs), percentage of bone area (BA%) and percentage of bone\u2010to\u2010implant contact (BIC%) were analysed for the SLA\u2010Sr and SLA implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple nanostructures were found on the Sr\u2010incorporated titanium surface, and appropriate amounts of strontium ions from the SLA\u2010Sr surface were released into the surrounding tissue within 21\u00a0days. In vivo, SLA\u2010Sr implants displayed much more new bone around their surfaces than the SLA implants. Significantly higher RTVs and BIC% were observed for the SLA\u2010Sr implants than for the SLA implants in both osteoporotic (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and healthy animals (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) at 3 and 6\u00a0weeks. The SLA\u2010Sr implants exhibited higher BA% in cortical bone (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and in cancellous bone (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) than the SLA implants in osteoporotic rabbits at 3\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is suggested that Sr\u2010incorporated surfaces treated through hydrothermal reactions have positive effects on promoting early osseointegration in both osteoporotic and non\u2010osteoporotic rabbits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13460","type":"journal-article","created":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T08:28:10Z","timestamp":1558254490000},"page":"777-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Strontium\u2010incorporated titanium implant surface treated by hydrothermal reactions promotes early bone osseointegration in osteoporotic rabbits"],"prefix":"10.1111","volume":"30","author":[{"given":"Guofen","family":"Lin","sequence":"first","affiliation":[{"name":"Department of General Dentistry, The Affiliated Stomatology Hospital, School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, The Affiliated Stomatology Hospital, School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, The Affiliated Stomatology Hospital, School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, The Affiliated Stomatology Hospital, School of Medicine Zhejiang 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