{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:34:03Z","timestamp":1791912843066,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although the regulatory effects of substance\u2010P (SP), neurokinin\u2010A (NKA), calcitonin gene\u2010linked peptide (CGRP) and neuropeptide\u2010Y (NPY) on periodontal inflammatory responses have been described, the effects of these neuropeptides on healthy and diseased periimplant tissues are not clearly defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Thirty\u2010nine implants loaded at least for 12\u00a0months with their symmetrically matching teeth were evaluated and compared by a split\u2010mouth study design. Six study groups were created in this regard as follows: group 1 (healthy periodontal tissues), group 2 (healthy periimplant tissues), group 3 (gingivitis), group 4 (periimplant mucositis), group 5 (periodontitis) and group 6 (periimplantitis). Clinical examinations included Silness\u2013L\u00f6e plaque index, L\u00f6e\u2013Silness gingival index, bleeding on probing, probing pocket depth and clinical attachment level measurements. Gingival crevicular fluid and periimplant sulcular fluid samples were collected, and the concentrations of neuropeptides were determined by enzyme\u2010linked immunosorbent assay. Their levels and correlations were investigated together with the clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neuropeptide levels were different in the teeth and implant groups according to the periodontal status (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). SP and NKA levels were increased, whereas CGRP and NPY levels were decreased in the diseased states. There were no differences between the neuropeptide levels of matching teeth and implants (groups 1\u20132, groups 3\u20134 and groups 5\u20136; <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated the presence of local neuropeptides in healthy and diseased periimplant tissues. The neurogenic inflammatory responses were also found to be similar in both periimplant and periodontal tissues.<\/jats:p><\/jats:sec>","DOI":"10.1111\/clr.13486","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T19:30:29Z","timestamp":1558639829000},"page":"800-807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neurogenic inflammation in periimplant and periodontal disease: A case\u2013control split\u2010mouth study"],"prefix":"10.1111","volume":"30","author":[{"given":"Serta\u00e7","family":"Sert","sequence":"first","affiliation":[{"name":"Department of Periodontology Ankara State Oral Health Care Center Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umur","family":"Sakallio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Ondokuz Mayis University Samsun 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